N-(2-methyl-5-nitrophenyl)guanidinium hydrochloride

Base Information

• Chemical Name: N-(2-methyl-5-nitrophenyl)guanidinium hydrochloride
• CAS No.: 1207534-99-3
• Molecular Formula: C₈H₁₀N₄O₂*ClH
• Molecular Weight: 230.654
• Mol file: 1207534-99-3.mol

Synonyms:N-(2-methyl-5-nitrophenyl)guanidinium hydrochloride

Chemical Property of N-(2-methyl-5-nitrophenyl)guanidinium hydrochloride

Chemical Property:

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-methyl-5-nitrophenyl)guanidinium hydrochloride

There total 2 articles about N-(2-methyl-5-nitrophenyl)guanidinium hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

CYANAMID (420-04-2) + 2-methyl-5-nitroaniline hydrochloride (51085-52-0) → N-(2-methyl-5-nitrophenyl)guanidinium hydrochloride (1207534-99-3)

Guidance literature:

at 50 - 70 ℃; for 1.5h;

DOI:10.1039/c6ra09812f

Reference yield: 96.0%

CYANAMID (420-04-2) + 2-methyl-5-nitroaniline (99-55-8) → N-(2-methyl-5-nitrophenyl)guanidinium hydrochloride (1207534-99-3)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 2h;

DOI:10.1002/cmdc.200900394

Reference yield: 87.0%

N-(2-methyl-5-nitrophenyl)guanidinium hydrochloride (1207534-99-3) + 3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one (55314-16-4,75415-01-9,123367-26-0) → 4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid (641569-94-0)

Guidance literature:

N-(2-methyl-5-nitrophenyl)guanidinium hydrochloride; 3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one; With potassium carbonate; In propan-1-ol; for 24h; Reflux;

With sodium hydroxide; In propan-1-ol;

With hydrogenchloride; In propan-1-ol;

DOI:10.1039/c6ra09812f

upstream raw materials:

CYANAMID

2-methyl-5-nitroaniline

2-methyl-5-nitroaniline hydrochloride

Downstream raw materials:

N-(5-nitro-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine

N-(2-methyl-5-nitrophenyl)-4-(pyridin-2-yl)pyrimidin-2-amine

N-(2-methyl-5-nitrophenyl)-4-(4-pyridyl)-2-pyrimidine-amine

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine