Chemical Property of cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
Chemical Property:
- Appearance/Colour:White Crystals
- Melting Point:228-230 °C
- Boiling Point:366.4oCat 760 mmHg
- Flash Point:189.6oC
- PSA：59.08000
- LogP:0.81700
- Storage Temp.:Store at RT
- Solubility.:Sparingly soluble in water, very slightly soluble in acetone and in ethanol (96 per cent).
- Water Solubility.:Soluble in water.
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:0
- Exact Mass:373.060151
- Heavy Atom Count:13
- Complexity:169
- Purity/Quality:
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99% *data from raw suppliers
Carboplatin *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
46-61-20/21/22-42/43-20/21
- Safety Statements:
53-22-26-36/37/39-45
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1CC(C1)(C(=O)O)C(=O)O.N.N.[Pt]
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Description
Carboplatin (Brand name: Paraplatin) is a kind of chemotherapy medication used for the treatment of a series of cancers. It can be used for the treatment of various kinds of cancers including ovarian cancer, lung cancer, head and neck cancer, brain cancer, and neuroblastoma. Moreover, it may also be used for treating some types of testicular cancer. Carboplatin belongs to a kind of alkylating agent. It takes effect through three major mechanisms: (1) Attach the alkyl groups to the DNA bases, further causing DNA fragmentation so that DNA replication is inhibited; (2) Cause DNA damage through inducing the formation of cross-links which prevents DNA from being separated for synthesis or transcription; (3) Induce mispairing of the nucleotides leading to mutations. Carboplatin is a second generation, platinum-containing antineoplastic agent with significantly reduced nephro-, neuro-, and ototoxicity in comparison to cisplatin. It is effective in the treatment of advanced ovarian carcinoma of epithelial origin and small cell carcinoma of the lung.
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Uses
Carboplatin is a second-generation platinum compound analog with established activity against a broad spectrum of solid tumors including brain tumors, neuroblastoma, rhabdomyosarcoma, and germ cell tumors. It is commonly used for pediatric cancer and approximately one-third of children with solid tumor are estimated to receive carboplatin at some point during their treatment. anthelmintic antitumor agent, Data on carboplatin production have not been found.
Carboplatin is used in chemotherapy to treat cancer, and
more particularly to treat cancer of ovary, embryonal carcinoma
of the testis, microcellular carcinoma of the lung,
neuroblastoma, and squamous cell carcinomas of the head
and neck. Analog of Cisplatin with reduced nephrotoxicity. Antineoplastic
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Indications
Carboplatin (Paraplatin) is an analogue of cisplatin. Its
plasma half-life is 3 to 5 hours, and it has no significant
protein binding. Renal excretion is the major route of
drug elimination.
Despite its lower chemical reactivity, carboplatin
has antitumor activity that is similar to that of cisplatin
against ovarian carcinomas, small cell lung cancers,
and germ cell cancers of the testis. Most tumors that
are resistant to cisplatin are cross-resistant to carboplatin.
The major advantage of carboplatin over cisplatin is
a markedly reduced risk of toxicity to the kidneys, peripheral
nerves, and hearing; additionally, it produces
less nausea and vomiting. It is, however, more myelosuppressive
than cisplatin. Other adverse effects include
anemia, abnormal liver function tests, and occasional allergic
reactions.
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Therapeutic Function
Antitumor
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Clinical Use
This drug induces fewer nonhematological toxicities (e.g., emesis, nephrotoxicity, and ototoxicity) compared to cisplatin, and it is approved for use only in the treatment of ovarian cancer. Unlabeled uses include combination therapy in lung, testicular, and head and neck cancers.
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Drug interactions
Potentially hazardous interactions with other drugs
Antibacterials: increased risk of nephrotoxicity
and possibly ototoxicity with aminoglycosides,
capreomycin, polymyxins or vancomycin.
Antipsychotics: avoid with clozapine, increased risk
of agranulocytosis.
