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azane;dichloroplatinum

Base Information Edit
  • Chemical Name:azane;dichloroplatinum
  • CAS No.:15663-27-1
  • Molecular Formula:Cl2H6N2Pt
  • Molecular Weight:300.047
  • Hs Code.:2843 90 90
  • Wikidata:Q412415
  • Mol file:15663-27-1.mol
azane;dichloroplatinum

Synonyms:trans-DDP;trans-diamminedichloroplatinum II;trans-dichlorodiammineplatinum II;transplatin

Suppliers and Price of azane;dichloroplatinum
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Cisplatin
  • 250mg
  • $ 245.00
  • TRC
  • Cisplatin
  • 50mg
  • $ 45.00
  • Tocris
  • Cisplatin
  • 50
  • $ 96.00
  • TCI Chemical
  • cis-Diammineplatinum(II) Dichloride
  • 100mg
  • $ 44.00
  • TCI Chemical
  • cis-Diammineplatinum(II) Dichloride
  • 1g
  • $ 209.00
  • Strem Chemicals
  • cis-Dichlorodiammineplatinum (II), CISPLATIN (USP)
  • 1g
  • $ 209.00
  • Strem Chemicals
  • cis-Dichlorodiammine platinum(II), 99% CISPLATIN
  • 5g
  • $ 618.00
  • Strem Chemicals
  • cis-Dichlorodiammine platinum(II), 99% CISPLATIN
  • 1g
  • $ 191.00
  • Strem Chemicals
  • cis-Dichlorodiammine platinum(II), 99% CISPLATIN
  • 250mg
  • $ 70.00
  • Strem Chemicals
  • cis-Dichlorodiammineplatinum (II), CISPLATIN (USP)
  • 5g
  • $ 836.00
Total 266 raw suppliers
Chemical Property of azane;dichloroplatinum Edit
Chemical Property:
  • Appearance/Colour:Orange-yellow to deep yellow solid or powder 
  • Melting Point:340 °C (dec.)(lit.) 
  • PSA:24.72000 
  • Density:3.7 g/cm3 
  • LogP:2.02430 
  • Storage Temp.:Store at RT 
  • Solubility.:Soluble in DMF. Insoluble in most common solvents 
  • Water Solubility.:<0.1 g/100 mL at 19℃ 
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:2
  • Rotatable Bond Count:0
  • Exact Mass:298.955598
  • Heavy Atom Count:5
  • Complexity:2.8
Purity/Quality:

98.0%-102.0%, *data from raw suppliers

Cisplatin *data from reagent suppliers

Safty Information:
  • Pictogram(s): Toxic
  • Hazard Codes:
  • Statements: 45-25-41-60-46-42/43-36/37/38 
  • Safety Statements: 53-26-39-45-99-36/37/39-22 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:N.N.Cl[Pt]Cl
  • Recent ClinicalTrials:Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)
  • Recent EU Clinical Trials:A Global, Phase 3, Randomized, Multicenter, Open-Label Study to Investigate the Efficacy and Safety of Furmonertinib Compared to Platinum-Based Chemotherapy as First-Line Treatment for Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer with Epidermal Growth Factor Receptor Exon 20 Insertion Mutations
  • Recent NIPH Clinical Trials:Phase 3 study of pembrolizumab vs chemotherapy in dMMR advanced or recurrent endometrial carcinoma
  • Description Cisplastin is an non-organic platinum-containing drug with alkylating properties. It causes cross-linking of DNA and RNA chains. In particular, it has been shown, that cisplastin, like other alkylating agents, bind primarily at N7 of two neighboring deoxyguanylates to DNA, which inhibits its replication. It is only used intravenously. It is highly reactive with carcinomas of the testicles, ovaries, heat, neck, spleen, lungs, and so on. Cisplatin is a platinum-containing compound that acts as a DNA-crosslinking agent and interferes with replication and transcription, culminating in apoptosis. It forms intra- and interstrand crosslinks with DNA with intrastrand guanine-to-guanine or guanine-to-alanine links accounting for the majority of DNA binding. Cisplatin halts the cell cycle at the G2/M phase in vitro and is active against murine tumors transplanted into mice and in mouse xenograft models, including a reduction in tumor growth in a model of squamous cell carcinoma of the head and neck when administered at doses ranging from 7.5 to 12.5 mg/kg. Cisplatin also inhibits the RecA recombinase of M. tuberculosis (IC50 = 2 μM), blocking protein splicing and cell growth. Formulations containing cisplatin have been used, alone and in combination therapy, in the treatment of a variety of cancers.
  • Uses Used as an antineoplastic Cisplatin is a cytostatic agent and it is used to treat various cancer types, including cancer of ovary, testis, lung, head, neck, bladder, neuroblastoma, and nephroblastoma, and Hodgkin’s disease and non-Hodgkin lymphoma. muscle relaxant (skeletal) antitumor agent
  • Indications Cisplatin (Platinol) is an inorganic coordination complex with a broad range of antitumor activity. It is especially useful in the treatment of testicular and ovarian cancer. It binds to DNA at nucleophilic sites, such as the N7 and O6 of guanine, producing alterations in DNA structure and inhibition of DNA synthesis. Adjacent guanine residues on the same DNA strand are preferentially cross-linked. This platinating activity is analogous to the mode of action of alkylating agents. Cisplatin also binds extensively to proteins. It does not appear to be phase specific in the cell cycle.
  • Therapeutic Function Antitumor
  • Clinical Use Cisplatin, combined with bleomycin and vinblastine or etoposide, produces cures in most patients with metastatic testicular cancer or germ cell cancer of the ovary. Cisplatin also shows some activity against carcinomas of the head and neck, bladder, cervix, prostate, and lung.
  • Drug interactions Potentially hazardous interactions with other drugs Aldesleukin: avoid concomitant use. Antibacterials: increased risk of nephrotoxicity and possibly ototoxicity with aminoglycosides, capreomycin, polymyxins or vancomycin. Antipsychotics: avoid with clozapine, increased risk of agranulocytosis. Cytotoxics: increased risk of ototoxicity with ifosfamide; increased pulmonary toxicity with bleomycin and methotrexate.
Technology Process of azane;dichloroplatinum

There total 224 articles about azane;dichloroplatinum which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
cis-diaminediiodoplatinum(II); With silver sulfate; In water; at 80 ℃;
potassium chloride; In water; at 80 ℃; for 0.333333h;
DOI:10.1021/jacs.9b10319
Guidance literature:
With sodium L-ascorbate; In water; acetonitrile;
Guidance literature:
With sodium L-ascorbate; In tetrahydrofuran; aq. phosphate buffer; dimethyl sulfoxide; at 20 ℃; pH=7.4; Kinetics;
DOI:10.1002/cmdc.201800105
Refernces Edit
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