(R)-7-(2-fluorophenyl)-4-methyl-6-piperidin-4-yl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one hydrochloride

Base Information

Chemical Name:(R)-7-(2-fluorophenyl)-4-methyl-6-piperidin-4-yl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one hydrochloride
CAS No.:1613721-53-1
Molecular Formula:C₂₂H₂₃FN₄O₂*ClH
Molecular Weight:430.91
Hs Code.:

Synonyms:(R)-7-(2-fluorophenyl)-4-methyl-6-piperidin-4-yl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one hydrochloride

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Chemical Property of (R)-7-(2-fluorophenyl)-4-methyl-6-piperidin-4-yl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one hydrochloride

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Technology Process of (R)-7-(2-fluorophenyl)-4-methyl-6-piperidin-4-yl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one hydrochloride

There total 5 articles about (R)-7-(2-fluorophenyl)-4-methyl-6-piperidin-4-yl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1613721-52-0
4-[(R)-7-(2-fluorophenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-yl]piperidine-1-carboxylic acid tert-butyl ester

: 1613721-53-1
(R)-7-(2-fluorophenyl)-4-methyl-6-piperidin-4-yl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h;
DOI:10.1021/jm5013006

Reference yield:

: 1613721-88-2
(R)-2-(7-bromo-3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propionic acid ethyl ester

: 1613721-53-1
(R)-7-(2-fluorophenyl)-4-methyl-6-piperidin-4-yl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: Lawessons reagent / toluene / 3 h / Reflux

2: hydrazine hydrate / ethanol / 20 °C

3: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate / water; 1,4-dioxane / 2 h / 90 °C

4: trifluoroacetic acid; N-Bromosuccinimide / 3 h / 20 °C

5: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 90 °C

6: palladium 10% on activated carbon; hydrogen / methanol / 50 °C / 2585.81 Torr

7: hydrogenchloride / ethyl acetate / 1 h / 20 °C

With Lawessons reagent; hydrogenchloride; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; palladium 10% on activated carbon; hydrogen; potassium carbonate; hydrazine hydrate; trifluoroacetic acid; In 1,4-dioxane; methanol; ethanol; water; ethyl acetate; toluene;
DOI:10.1021/jm5013006

Reference yield:

: 1613721-89-3
(R)-2-(7-bromo-3-thioxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propionic acid ethyl ester

: 1613721-53-1
(R)-7-(2-fluorophenyl)-4-methyl-6-piperidin-4-yl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: hydrazine hydrate / ethanol / 20 °C

2: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate / water; 1,4-dioxane / 2 h / 90 °C

3: trifluoroacetic acid; N-Bromosuccinimide / 3 h / 20 °C

4: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 90 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 50 °C / 2585.81 Torr

6: hydrogenchloride / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; palladium 10% on activated carbon; hydrogen; potassium carbonate; hydrazine hydrate; trifluoroacetic acid; In 1,4-dioxane; methanol; ethanol; water; ethyl acetate;
DOI:10.1021/jm5013006