4-[(R)-7-(2-fluorophenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-yl]piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-[(R)-7-(2-fluorophenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-yl]piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1613721-52-0
Molecular Formula:C₂₇H₃₁FN₄O₄
Molecular Weight:494.566
Hs Code.:

Synonyms:4-[(R)-7-(2-fluorophenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-yl]piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-[(R)-7-(2-fluorophenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-yl]piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-[(R)-7-(2-fluorophenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-yl]piperidine-1-carboxylic acid tert-butyl ester

There total 4 articles about 4-[(R)-7-(2-fluorophenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-yl]piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1613721-51-9
4-[(R)-7-(2-fluorophenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1613721-52-0
4-[(R)-7-(2-fluorophenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-yl]piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 50 ℃; under 2585.81 Torr;
DOI:10.1021/jm5013006

Reference yield:

: 1613721-88-2
(R)-2-(7-bromo-3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propionic acid ethyl ester

: 1613721-52-0
4-[(R)-7-(2-fluorophenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-yl]piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Lawessons reagent / toluene / 3 h / Reflux

2: hydrazine hydrate / ethanol / 20 °C

3: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate / water; 1,4-dioxane / 2 h / 90 °C

4: trifluoroacetic acid; N-Bromosuccinimide / 3 h / 20 °C

5: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 90 °C

6: palladium 10% on activated carbon; hydrogen / methanol / 50 °C / 2585.81 Torr

With Lawessons reagent; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; palladium 10% on activated carbon; hydrogen; potassium carbonate; hydrazine hydrate; trifluoroacetic acid; In 1,4-dioxane; methanol; ethanol; water; toluene;
DOI:10.1021/jm5013006

Reference yield:

: 1613721-89-3
(R)-2-(7-bromo-3-thioxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propionic acid ethyl ester

: 1613721-52-0
4-[(R)-7-(2-fluorophenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-yl]piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate / ethanol / 20 °C

2: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate / water; 1,4-dioxane / 2 h / 90 °C

3: trifluoroacetic acid; N-Bromosuccinimide / 3 h / 20 °C

4: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 90 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 50 °C / 2585.81 Torr

With N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; palladium 10% on activated carbon; hydrogen; potassium carbonate; hydrazine hydrate; trifluoroacetic acid; In 1,4-dioxane; methanol; ethanol; water;
DOI:10.1021/jm5013006