N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)propionamide

Base Information

• Chemical Name: N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)propionamide
• CAS No.: 1301179-07-6
• Molecular Formula: C₁₇H₂₅Cl₂N₃O
• Molecular Weight: 358.311
• Mol file: 1301179-07-6.mol

Synonyms:N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)propionamide

Chemical Property of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)propionamide

There total 2 articles about N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

propionyl chloride (79-03-8) + 4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butylamine (189061-44-7) → N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)propionamide (1301179-07-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm200288r

Reference yield:

2-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione (367275-36-3) → N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)propionamide (1301179-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine / ethanol / 3 h / Reflux

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With triethylamine; hydrazine; In ethanol; dichloromethane;

DOI:10.1021/jm200288r

Reference yield: 82.0%

N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)propionamide (1301179-07-6) → 4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-N-propylbutan-1-amine (1301179-09-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 4h; Inert atmosphere; Reflux;

DOI:10.1021/jm200288r

upstream raw materials:

propionyl chloride

4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butylamine

2-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione

Downstream raw materials:

4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-N-propylbutan-1-amine

N-((9H-fluoren-2-yl)methyl)-4-(4-(2,3-dichlorophenyl)-piperazin-1-yl)-N-propylbutan-1-amine

4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-N-(naphthalen-2-ylmethyl)-N-propylbutan-1-amine