N-{3-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]phenyl}-2,2,2-trifluoroacetamide

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Chemical Name:N-{3-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]phenyl}-2,2,2-trifluoroacetamide
CAS No.:1228590-48-4
Molecular Formula:C₁₆H₉F₃N₄O₂S
Molecular Weight:378.334
Hs Code.:

Synonyms:N-{3-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]phenyl}-2,2,2-trifluoroacetamide

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Chemical Property of N-{3-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]phenyl}-2,2,2-trifluoroacetamide

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Technology Process of N-{3-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]phenyl}-2,2,2-trifluoroacetamide

There total 5 articles about N-{3-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]phenyl}-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1228590-47-3
N-[3-(4-amino-2-cyanophenoxy)phenyl]-2,2,2-trifluoroacetamide

: 333-20-0
potassium thioacyanate

: 1228590-48-4
N-{3-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]phenyl}-2,2,2-trifluoroacetamide

Guidance literature:: N-[3-(4-amino-2-cyanophenoxy)phenyl]-2,2,2-trifluoroacetamide; potassium thioacyanate; With acetic acid; at 20 ℃; for 0.166667h;

With bromine; at 20 ℃; for 12h;
DOI:10.1021/jm400778d

Reference yield:

: 1079042-73-1
2-(3-aminophenoxy)-5-nitrobenzonitrile

: 1228590-48-4
N-{3-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]phenyl}-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 1.5 h / 0 - 20 °C

2.1: hydrogen; palladium 10% on activated carbon / methanol / 20 °C / 760.05 Torr

3.1: acetic acid / 0.17 h / 20 °C

3.2: 12 h / 20 °C

With palladium 10% on activated carbon; hydrogen; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1021/jm400778d

Reference yield:

: 1228590-46-2
N-[3-(2-cyano-4-nitrophenoxy)phenyl]-2,2,2-trifluoroacetamide

: 1228590-48-4
N-{3-[(2-amino-7-cyano-1,3-benzothiazol-6-yl)oxy]phenyl}-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen; palladium 10% on activated carbon / methanol / 20 °C / 760.05 Torr

2.1: acetic acid / 0.17 h / 20 °C

2.2: 12 h / 20 °C

With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol;
DOI:10.1021/jm400778d