Technology Process of 1-(2-fluoro-5-isopropoxy)benzyl-6,7-dimethoxyisoquinoline-4-acetic acid methyl ester
There total 13 articles about 1-(2-fluoro-5-isopropoxy)benzyl-6,7-dimethoxyisoquinoline-4-acetic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
diethyl ether; dichloromethane;
at 20 ℃;
for 0.166667h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: ethanol; sodium / toluene / 2 h / 80 - 85 °C
1.2: 2 h / 80 °C
2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 2844.39 Torr
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C
4.1: phosphorus pentachloride / dichloromethane
5.1: sulfur / 0.33 h / 165 °C
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C
7.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 20 °C
8.1: dimethyl sulfoxide / 1 h / 85 °C
9.1: sodium hydroxide / ethanol; water / Heating / reflux
10.1: diethyl ether; dichloromethane / 0.17 h / 20 °C
With
hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; ethanol; phosphorus pentachloride; hydrogen; sodium; benzotriazol-1-ol; sulfur; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 2844.39 Torr
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C
3: phosphorus pentachloride / dichloromethane
4: sulfur / 0.33 h / 165 °C
5: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C
6: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 20 °C
7: dimethyl sulfoxide / 1 h / 85 °C
8: sodium hydroxide / ethanol; water / Heating / reflux
9: diethyl ether; dichloromethane / 0.17 h / 20 °C
With
hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; phosphorus pentachloride; hydrogen; benzotriazol-1-ol; sulfur; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide;
