36848-69-8

Usage

Uses

Used in Pharmaceutical Industry:
(3,4-Dimethoxyphenyl)cyanoacetic acid ethyl ester is utilized as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of biologically active molecules. Its structural features facilitate the creation of compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, (3,4-Dimethoxyphenyl)cyanoacetic acid ethyl ester serves as a crucial building block for the synthesis of various agrochemicals, including pesticides and herbicides. Its chemical properties allow for the production of effective compounds designed to protect crops and enhance agricultural yields.
Used in Organic Compounds Synthesis:
(3,4-Dimethoxyphenyl)cyanoacetic acid ethyl ester is employed as a versatile intermediate in the synthesis of a range of organic compounds. Its unique structure and reactivity make it suitable for the creation of specialty chemicals used in various industries, such as the fragrance, flavor, and dye industries.

Upstream product

• 2859-78-1 4-Bromoveratrole 
• 105-56-6 ethyl 2-cyanoacetate 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 105-58-8 Diethyl carbonate 
• 5460-32-2 1-iodo-3,4-dimethoxybenzene 

Downstream Products

• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 209003-34-9 C₁₉H₂₀N₄O₃S 
• 209003-32-7 C₁₈H₁₈N₄O₃S 
• 209003-25-8 α-cyano-3,4-dimethoxyphenylacetic acid hydrazide 
• 209003-26-9 3-amino-4-(3,4-dimethoxyphenyl)-1H-pyrazol-5-ol 

Relevant academic research and scientific papers

INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A

The present invention relates to compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof, where in formula I the variables R1, R2, R3, R4 and R5/

Synthesis of substituted isoquinolines via Pd-catalyzed cross-coupling approaches

Palladium complexes incorporating ligands based on a 1,3,5,7-tetramethyl-2, 4,8-trioxa-6-phosphaadamantanyl scaffold were used to catalyze the arylation of ethyl cyanoacetate, malononitrile, and various ketones. The products from these reactions can be el

Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors

Through high throughput screening and subsequent hit identification and optimization, we synthesized a series of 1-arylcarbonyl-6,7- dimethoxyisoquinoline derivatives as the first reported potent and reversible GFAT inhibitors. SAR studies of this class o

GFAT INHIBITORS

Compounds of formula (I) are provided as well as pharmaceutically acceptable salts and esters thereof, wherein the substituents are as disclosed in the specification. The compounds have utility for the treatment of type 2 diabetes mellitus.

Multidrug resistance modifying dithianes

Compounds of the formula STR1 wherein R is a residue of the formula STR2 and R1, R2, R3, R4, R5, R6, R7, X, Y and Z are as described, with the exception of rac-N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)-β,N-dimethyl-m-dithiane-2-propanamine, as well as their acid addition salts, in particular for use in eliminating cytostatic resistance in tumor treatment and chloroquine resistance in malaria.

A SIMPLE ONE-POT CONVERSION OF ARYL HALIDES INTO ARYLACETONITRILES

When heated in hexamethylphosphoric triamide in the presence of copper(I) iodide, aryl iodides and bromides react with cyanoacetate anion to form arylcyanoacetates, which lose the ester group on hydrolysis, giving the corresponding arylacetonitriles in good to moderate yields.