N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)-2,4-dichlorobenzenesulfonamide

Base Information

• Chemical Name: N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)-2,4-dichlorobenzenesulfonamide
• CAS No.: 1417177-54-8
• Molecular Formula: C₂₇H₂₆Cl₃N₃O₃S
• Molecular Weight: 578.947
• Mol file: 1417177-54-8.mol

Synonyms:N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)-2,4-dichlorobenzenesulfonamide

Chemical Property of N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)-2,4-dichlorobenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)-2,4-dichlorobenzenesulfonamide

There total 8 articles about N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)-2,4-dichlorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2,4-Dichlorobenzenesulfonyl chloride (16271-33-3) + 4-(7-chloro-2-methylquinolin-4-ylamino)-2-((diethylamino)methyl)phenol (102374-64-1) → N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)-2,4-dichlorobenzenesulfonamide (1417177-54-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetone; for 3h; Inert atmosphere;

Reference yield:

7-chloro-4-hydroxy-2-methylquinoline (15644-88-9) → N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)-2,4-dichlorobenzenesulfonamide (1417177-54-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trichlorophosphate / 2.5 h / 120 °C

2.1: hydrogenchloride; water / 2 h / Reflux

2.2: 6 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / acetone / 3 h / Inert atmosphere

With hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In acetone;

Reference yield:

3-chloro-aniline (108-42-9) → N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)-2,4-dichlorobenzenesulfonamide (1417177-54-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride / 25 °C

2.1: trichlorophosphate / 2.5 h / 120 °C

3.1: hydrogenchloride; water / 2 h / Reflux

3.2: 6 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / acetone / 3 h / Inert atmosphere

With hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In acetone;

upstream raw materials:

3-chloro-aniline

2,4-Dichlorobenzenesulfonyl chloride

4-(7-chloro-2-methylquinolin-4-ylamino)-2-((diethylamino)methyl)phenol

7-chloro-4-hydroxy-2-methylquinoline

Refernces

• 1、 -. "N-(3-((DIETHYLAMINO) METHYL)-4-HYDROXYPHENYL)-N-(QUINOLIN-4-YL) SULFONAMIDES FOR THE TREATMENT OF TUBERCULOSIS AND PROCESS OF PREPARATION THEREOF". . . Retrieved 2013/07/19.