(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-pentanoic acid hydroxy-p-tolyl-amide

Base Information

• Chemical Name: (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-pentanoic acid hydroxy-p-tolyl-amide
• CAS No.: 126901-06-2
• Molecular Formula: C₂₁H₂₂N₂O₄
• Molecular Weight: 366.417
• Mol file: 126901-06-2.mol

Synonyms:(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-pentanoic acid hydroxy-p-tolyl-amide

Chemical Property of (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-pentanoic acid hydroxy-p-tolyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-pentanoic acid hydroxy-p-tolyl-amide

There total 4 articles about (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-pentanoic acid hydroxy-p-tolyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-phthalimide-L-leucinyl chloride (3183-10-6) + N-(4-methylphenyl)hydroxylamine (623-10-9) → (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-pentanoic acid hydroxy-p-tolyl-amide (126901-06-2)

Guidance literature:

With sodium hydrogencarbonate; In diethyl ether; for 12h; -78 deg C -> 25 deg C;

Reference yield:

phthalic anhydride (85-44-9) → (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-pentanoic acid hydroxy-p-tolyl-amide (126901-06-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.5 h / 150 - 180 °C

2: PCl₅ / benzene / 1 h

3: NaHCO₃ / diethyl ether / 12 h / -78 deg C -> 25 deg C

With phosphorus pentachloride; sodium hydrogencarbonate; In diethyl ether; benzene;

Reference yield:

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-pentanoic acid hydroxy-p-tolyl-amide (126901-06-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.5 h / 150 - 180 °C

2: PCl₅ / benzene / 1 h

3: NaHCO₃ / diethyl ether / 12 h / -78 deg C -> 25 deg C

With phosphorus pentachloride; sodium hydrogencarbonate; In diethyl ether; benzene;

upstream raw materials:

N-phthalimide-L-leucinyl chloride

N-(4-methylphenyl)hydroxylamine

phthalic anhydride

L-leucine

Downstream raw materials:

Leucin-N-(4-methylphenyl)hydroxamsaeure