N-phthalimide-L-leucinyl chloride

Base Information

• Chemical Name: N-phthalimide-L-leucinyl chloride
• CAS No.: 3183-10-6
• Molecular Formula: C₁₄H₁₄ClNO₃
• Molecular Weight: 279.723
• Mol file: 3183-10-6.mol

Synonyms:N-phthalimide-L-leucinyl chloride

Chemical Property of N-phthalimide-L-leucinyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-phthalimide-L-leucinyl chloride

There total 1 articles about N-phthalimide-L-leucinyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) → N-phthalimide-L-leucinyl chloride (3183-10-6)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 12 h / Heating

2: thionyl chloride / toluene / 1.5 h / Heating

With thionyl chloride; In toluene;

DOI:10.1246/bcsj.63.2728

Reference yield: 72.0%

N-phthalimide-L-leucinyl chloride (3183-10-6) + benzyl(bromo)zinc (62673-31-8) → (S)-5-methyl-1-phenyl-3-phthalimidohexan-2-one (203917-22-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/S0957-4166(99)00524-8

Reference yield: 56.0%

N-phthalimide-L-leucinyl chloride (3183-10-6) + benzophenone oxime (1485-71-8) → phthaloyl-Leu-N(OH)(CHPh2)

Guidance literature:

In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/ja002602o

upstream raw materials:

phthalic anhydride

Downstream raw materials:

(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-pentanoic acid hydroxy-p-tolyl-amide

1-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-5-{[(S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-pentanoylamino]-methyl}-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide

(S)-4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-6-methyl-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-heptanoic acid ethyl ester

(S)-5-methyl-1-phenyl-3-phthalimidohexan-2-one