Technology Process of (R)-2-[(R)-2-(benzyloxy)-1-(tert-butoxycarbonylamino)-2-oxoethyl]-5-phenylpentanoic acid
There total 9 articles about (R)-2-[(R)-2-(benzyloxy)-1-(tert-butoxycarbonylamino)-2-oxoethyl]-5-phenylpentanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene;
In
water; tert-butyl alcohol;
at 20 ℃;
for 16h;
Inert atmosphere;
DOI:10.1002/ejoc.201101318
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: Novozym 435 / 18 h / 20 °C / Inert atmosphere; Enzymatic reaction
2.1: water; sodium hydroxide / methanol / 0 - 20 °C / Inert atmosphere
3.1: dmap; dicyclohexyl-carbodiimide / diethyl ether / 20 h / 0 - 20 °C / Inert atmosphere
4.1: n-butyllithium; diisopropylamine; zinc(II) chloride / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere
5.1: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
6.1: ozone / dichloromethane / 0.08 h / -78 °C / Inert atmosphere
6.2: 0.5 h / -78 - 20 °C / Inert atmosphere
7.1: sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 16 h / 20 °C / Inert atmosphere
With
dmap; sodium chlorite; n-butyllithium; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; Novozym 435; water; caesium carbonate; ozone; diisopropylamine; dicyclohexyl-carbodiimide; sodium hydroxide; zinc(II) chloride;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
4.1: Claisen rearrangement;
DOI:10.1002/ejoc.201101318
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dmap; dicyclohexyl-carbodiimide / diethyl ether / 20 h / 0 - 20 °C / Inert atmosphere
2.1: n-butyllithium; diisopropylamine; zinc(II) chloride / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere
3.1: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
4.1: ozone / dichloromethane / 0.08 h / -78 °C / Inert atmosphere
4.2: 0.5 h / -78 - 20 °C / Inert atmosphere
5.1: sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 16 h / 20 °C / Inert atmosphere
With
dmap; sodium chlorite; n-butyllithium; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; caesium carbonate; ozone; diisopropylamine; dicyclohexyl-carbodiimide; zinc(II) chloride;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
2.1: Claisen rearrangement;
DOI:10.1002/ejoc.201101318
