Technology Process of benzyl (2R,3S,E)-2-(tert-butoxycarbonylamino)-3-(3-phenylpropyl)hex-4-enoate
There total 7 articles about benzyl (2R,3S,E)-2-(tert-butoxycarbonylamino)-3-(3-phenylpropyl)hex-4-enoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1002/ejoc.201101318
- Guidance literature:
-
Multi-step reaction with 5 steps
1: Novozym 435 / 18 h / 20 °C / Inert atmosphere; Enzymatic reaction
2: water; sodium hydroxide / methanol / 0 - 20 °C / Inert atmosphere
3: dmap; dicyclohexyl-carbodiimide / diethyl ether / 20 h / 0 - 20 °C / Inert atmosphere
4: n-butyllithium; diisopropylamine; zinc(II) chloride / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere
5: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
With
dmap; n-butyllithium; Novozym 435; water; caesium carbonate; diisopropylamine; dicyclohexyl-carbodiimide; sodium hydroxide; zinc(II) chloride;
In
tetrahydrofuran; methanol; diethyl ether; hexane; N,N-dimethyl-formamide;
4: Claisen rearrangement;
DOI:10.1002/ejoc.201101318
- Guidance literature:
-
Multi-step reaction with 3 steps
1: dmap; dicyclohexyl-carbodiimide / diethyl ether / 20 h / 0 - 20 °C / Inert atmosphere
2: n-butyllithium; diisopropylamine; zinc(II) chloride / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere
3: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
With
dmap; n-butyllithium; caesium carbonate; diisopropylamine; dicyclohexyl-carbodiimide; zinc(II) chloride;
In
tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
2: Claisen rearrangement;
DOI:10.1002/ejoc.201101318
