tert-butyl (2S,4S)-4-{[(4-bromophenyl)sulfonyl]oxy}-2-{[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]carbamoyl}pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (2S,4S)-4-{[(4-bromophenyl)sulfonyl]oxy}-2-{[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]carbamoyl}pyrrolidine-1-carboxylate
CAS No.:1338650-03-5
Molecular Formula:C₂₄H₃₁BrN₂O₈S
Molecular Weight:587.489
Hs Code.:

Synonyms:tert-butyl (2S,4S)-4-{[(4-bromophenyl)sulfonyl]oxy}-2-{[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]carbamoyl}pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (2S,4S)-4-{[(4-bromophenyl)sulfonyl]oxy}-2-{[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]carbamoyl}pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (2S,4S)-4-{[(4-bromophenyl)sulfonyl]oxy}-2-{[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]carbamoyl}pyrrolidine-1-carboxylate

There total 5 articles about tert-butyl (2S,4S)-4-{[(4-bromophenyl)sulfonyl]oxy}-2-{[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]carbamoyl}pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 746657-36-3,213316-32-6,259221-73-3
(1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate

: 367258-59-1
4-(4-bromobenzenesulfonyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

: 1338650-03-5
tert-butyl (2S,4S)-4-{[(4-bromophenyl)sulfonyl]oxy}-2-{[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]carbamoyl}pyrrolidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 10 - 20 ℃;
DOI:10.1002/cjoc.201180270

Reference yield:

: 259214-54-5,259214-56-7
ethyl (1R,2S)-1-amino-2-vinylcyclopropanecarboxylate hydrochloride

: 367258-59-1
4-(4-bromobenzenesulfonyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

: 1338650-03-5
tert-butyl (2S,4S)-4-{[(4-bromophenyl)sulfonyl]oxy}-2-{[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]carbamoyl}pyrrolidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 138-36-3
p-bromobenzene sulfonic acid

: 1338650-03-5
tert-butyl (2S,4S)-4-{[(4-bromophenyl)sulfonyl]oxy}-2-{[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]carbamoyl}pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine / toluene / Reflux; Inert atmosphere

1.2: 8 h

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 10 - 20 °C

With di-isopropyl azodicarboxylate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; In dichloromethane; toluene; 1.1: Mitsunobu reaction;
DOI:10.1002/cjoc.201180270