1-[(4-(4-bromobenzenesulfonyloxy)-1-{2-cyclopentyloxycarbonylamino-3-[(2-nitro-benzenesulfonyl)pent-4-enyl-amino]propionyl}pyrrolidine-2-carbonyl)amino]-2-vinylcyclopropanecarboxylic acid ethyl ester

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Chemical Name:1-[(4-(4-bromobenzenesulfonyloxy)-1-{2-cyclopentyloxycarbonylamino-3-[(2-nitro-benzenesulfonyl)pent-4-enyl-amino]propionyl}pyrrolidine-2-carbonyl)amino]-2-vinylcyclopropanecarboxylic acid ethyl ester
CAS No.:1338650-07-9
Molecular Formula:C₃₉H₄₈BrN₅O₁₃S₂
Molecular Weight:938.872
Hs Code.:

1-[(4-(4-bromobenzenesulfonyloxy)-1-{2-cyclopentyloxycarbonylamino-3-[(2-nitro-benzenesulfonyl)pent-4-enyl-amino]propionyl}pyrrolidine-2-carbonyl)amino]-2-vinylcyclopropanecarboxylic acid ethyl ester

Synonyms:1-[(4-(4-bromobenzenesulfonyloxy)-1-{2-cyclopentyloxycarbonylamino-3-[(2-nitro-benzenesulfonyl)pent-4-enyl-amino]propionyl}pyrrolidine-2-carbonyl)amino]-2-vinylcyclopropanecarboxylic acid ethyl ester

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Chemical Property of 1-[(4-(4-bromobenzenesulfonyloxy)-1-{2-cyclopentyloxycarbonylamino-3-[(2-nitro-benzenesulfonyl)pent-4-enyl-amino]propionyl}pyrrolidine-2-carbonyl)amino]-2-vinylcyclopropanecarboxylic acid ethyl ester

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Technology Process of 1-[(4-(4-bromobenzenesulfonyloxy)-1-{2-cyclopentyloxycarbonylamino-3-[(2-nitro-benzenesulfonyl)pent-4-enyl-amino]propionyl}pyrrolidine-2-carbonyl)amino]-2-vinylcyclopropanecarboxylic acid ethyl ester

There total 10 articles about 1-[(4-(4-bromobenzenesulfonyloxy)-1-{2-cyclopentyloxycarbonylamino-3-[(2-nitro-benzenesulfonyl)pent-4-enyl-amino]propionyl}pyrrolidine-2-carbonyl)amino]-2-vinylcyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1338650-23-9
2-cyclopentyloxycarbonylamino-3-[(2-nitro-benzenesulfonyl)-pent-4-enyl-amino]propionic acid

: 1338650-04-6
1-{[4-(4-bromobenzenesulfonyloxy)pyrrolidine-2-carbonyl]amino}-2-vinyl-cyclopropane-carboxylic acid ethyl ester hydrogen chloride

: 1338650-07-9
1-[(4-(4-bromobenzenesulfonyloxy)-1-{2-cyclopentyloxycarbonylamino-3-[(2-nitro-benzenesulfonyl)pent-4-enyl-amino]propionyl}pyrrolidine-2-carbonyl)amino]-2-vinylcyclopropanecarboxylic acid ethyl ester

Guidance literature:: 2-cyclopentyloxycarbonylamino-3-[(2-nitro-benzenesulfonyl)-pent-4-enyl-amino]propionic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl acetamide; at 20 ℃;

1-{[4-(4-bromobenzenesulfonyloxy)pyrrolidine-2-carbonyl]amino}-2-vinyl-cyclopropane-carboxylic acid ethyl ester hydrogen chloride; With triethylamine; In N,N-dimethyl acetamide; at 30 ℃;
DOI:10.1002/cjoc.201180270

Reference yield:

: 367258-59-1
4-(4-bromobenzenesulfonyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

: 1338650-07-9
1-[(4-(4-bromobenzenesulfonyloxy)-1-{2-cyclopentyloxycarbonylamino-3-[(2-nitro-benzenesulfonyl)pent-4-enyl-amino]propionyl}pyrrolidine-2-carbonyl)amino]-2-vinylcyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 10 - 20 °C

2.1: hydrogenchloride / 1,4-dioxane; water / 20 °C

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl acetamide / 20 °C

3.2: 30 °C

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1002/cjoc.201180270

Reference yield:

: 1338650-03-5
tert-butyl (2S,4S)-4-{[(4-bromophenyl)sulfonyl]oxy}-2-{[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]carbamoyl}pyrrolidine-1-carboxylate

: 1338650-07-9
1-[(4-(4-bromobenzenesulfonyloxy)-1-{2-cyclopentyloxycarbonylamino-3-[(2-nitro-benzenesulfonyl)pent-4-enyl-amino]propionyl}pyrrolidine-2-carbonyl)amino]-2-vinylcyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane; water / 20 °C

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl acetamide / 20 °C

2.2: 30 °C

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In 1,4-dioxane; N,N-dimethyl acetamide; water;
DOI:10.1002/cjoc.201180270