367258-59-1

Basic information

• Product Name: 1,2-Pyrrolidinedicarboxylic acid, 4-[[(4-bromophenyl)sulfonyl]oxy]-, 1-(1,1-dimethylethyl) ester, (2S,4S)-
• CAS NO: 367258-59-1
• Molecular Formula: C16H20BrNO7S
• Molecular Weight: 450.307
• Mol File: 367258-59-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,2-Pyrrolidinedicarboxylic acid, 4-[[(4-bromophenyl)sulfonyl]oxy]-, 1-(1,1-dimethylethyl) ester, (2S,4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Pyrrolidinedicarboxylic acid, 4-[[(4-bromophenyl)sulfonyl]oxy]-, 1-(1,1-dimethylethyl) ester, (2S,4S)-(367258-59-1)
• EPA Substance Registry System: 1,2-Pyrrolidinedicarboxylic acid, 4-[[(4-bromophenyl)sulfonyl]oxy]-, 1-(1,1-dimethylethyl) ester, (2S,4S)-(367258-59-1)

Safety Data

• Hazardous Substances Data: 367258-59-1(Hazardous Substances Data)

Upstream product

• 138-36-3 p-bromobenzene sulfonic acid 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 438452-29-0 1-tert-butyl 2-methyl (2S,4S)-4-{[(4-bromo-phenyl)sulfonyl]oxy}-pyrrolidine-1,2-dicarboxylate 

Downstream Products

• 1219513-73-1 C₂₃H₃₁BrN₂O₈S 
• 1338650-03-5 tert-butyl (2S,4S)-4-{[(4-bromophenyl)sulfonyl]oxy}-2-{[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]carbamoyl}pyrrolidine-1-carboxylate 
• 769167-58-0 (1S,2R)-1-{[(2S,4S)-4-(4-bromo-benzenesulfonyloxy)-1-((S)-2-cyclopentyloxycarbonylamino-oct-7-enoyl)pyrrolidine-2-carbonyl]-amino}-2-vinylcyclopropanecarboxylic acid methyl ester 
• 879623-40-2 18-(4-bromobenzenesulfonyloxy)-14-cyclopentyloxycarbonylamino-2,15-dioxo-3,16-diaza-tricyclo-[14.3.0.0(4,6)]nonadec-7-ene-4-carboxylic acid methyl ester 
• 1098199-68-8 C₁₈H₂₁BrN₂O₆S*ClH 
• 1338650-04-6 1-{[4-(4-bromobenzenesulfonyloxy)pyrrolidine-2-carbonyl]amino}-2-vinyl-cyclopropane-carboxylic acid ethyl ester hydrogen chloride 
• 1007205-38-0 ciluprevir 
• 1338650-05-7 1-{[4-(4-bromobenzenesulfonyloxy)-1-(2-cyclopentyloxycarbonylamino-3-pent-4-enyloxypropionyl)pyrrolidine-2-carbonyl]amino}-2-vinylcyclopropanecarboxylic acid ethyl ester 
• 1338650-06-8 1-{[4-(4-bromobenzenesulfonyloxy)-1-(2-cyclopentyloxycarbonylamino-3-pent-4-enylsulfanylpropionyl)pyrrolidine-2-carbonyl]amino}-2-vinylcyclopropanecarboxylic acid ethyl ester 
• 1338650-07-9 1-[(4-(4-bromobenzenesulfonyloxy)-1-{2-cyclopentyloxycarbonylamino-3-[(2-nitro-benzenesulfonyl)pent-4-enyl-amino]propionyl}pyrrolidine-2-carbonyl)amino]-2-vinylcyclopropanecarboxylic acid ethyl ester 
• 1338650-08-0 1-{[1-[3-(acetyl-pent-4-enyl-amino)-2-cyclopentyloxycarbonylaminopropionyl]-4-(4-bromobenzenesulfonyloxy)pyrrolidine-2-carbonyl]amino}-2-vinylcyclopropanecarboxylic acid ethyl ester 
• 1338650-09-1 1-({4-(4-bromobenzenesulfonyloxy)-1-[2-cyclopentyloxycarbonylamino-3-(methyl-pent-4-enyl-amino)propionyl]pyrrolidine-2-carbonyl}amino)-2-vinylcyclopropanecarboxylic acid ethyl ester 
• 801282-60-0 C₂₃H₂₉BrN₂O₈S 
• 874124-85-3 C₂₅H₃₂BrN₃O₉S₂ 

Relevant articles and documents

Novel, sulfonamide linked inhibitors of the hepatitis C virus NS3 protease

A sulfonamide replacement of the P2-P3 amide bond in the context of macrocyclic HCV NS3 protease inhibitors was investigated. These analogs displayed good inhibitory potency in the absence of any P3 capping group. The synthesis and preliminary SAR are des

HCV NS3 PROTEASE INHIBITORS

The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

HEPATITIS C INHIBITOR COMPOUNDS

Compounds of Formula (I): wherein B, R3, L0, L1, R2, Rc and R1 are defined herein. The compounds are useful as inhibitors of HCV NS3 protease for the treatment of hepatitis C viral infection. In particular, the present invention provides novel peptide analogs, pharmaceutical compositions containing such analogs, and uses of these analogs in the treatment of HCV infection