(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(thiophen-2-yl)ethenesulfonamide

Base Information

Chemical Name:(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(thiophen-2-yl)ethenesulfonamide
CAS No.:403604-79-5
Molecular Formula:C₂₁H₁₆ClN₅O₄S₂
Molecular Weight:501.974
Hs Code.:

Synonyms:(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(thiophen-2-yl)ethenesulfonamide

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Chemical Property of (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(thiophen-2-yl)ethenesulfonamide

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Technology Process of (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(thiophen-2-yl)ethenesulfonamide

There total 3 articles about (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(thiophen-2-yl)ethenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 134640-93-0
(E)-2-(thiophen-2-yl)ethenesulfonamide

: 150728-13-5
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

: 403604-79-5
(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(thiophen-2-yl)ethenesulfonamide

Guidance literature:: (E)-2-(thiophen-2-yl)ethenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1016/S0968-0896(01)00187-0

Reference yield:

: 20730-58-9
2-(2-Methoxyphenoxy)propanedioic acid diethyl ester

: 403604-79-5
(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(thiophen-2-yl)ethenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 57 percent / NaOEt / ethanol / 2.75 h / Heating

2.1: 75 percent / phosphorus oxychloride; 2,4,6-trimethylpyrimidine / 17.5 h / 90 °C

3.1: NaH / dimethylformamide / 0.17 h / 20 °C

3.2: 38 percent / dimethylformamide / 4 h / 20 °C

With 2,4,6-trimethylpyrimidine; sodium ethanolate; sodium hydride; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00187-0

Reference yield:

: 329923-15-1
4,6-dihydroxy-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-pyrimidine

: 403604-79-5
(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(thiophen-2-yl)ethenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 75 percent / phosphorus oxychloride; 2,4,6-trimethylpyrimidine / 17.5 h / 90 °C

2.1: NaH / dimethylformamide / 0.17 h / 20 °C

2.2: 38 percent / dimethylformamide / 4 h / 20 °C

With 2,4,6-trimethylpyrimidine; sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00187-0