(R)-2-Azido-N-[(S)-1-hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-3-phenyl-propionamide

Base Information

Chemical Name:(R)-2-Azido-N-[(S)-1-hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-3-phenyl-propionamide
CAS No.:439296-18-1
Molecular Formula:C₁₉H₂₂N₄O₃
Molecular Weight:354.409
Hs Code.:

Synonyms:(R)-2-Azido-N-[(S)-1-hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-3-phenyl-propionamide

Suppliers and Price of (R)-2-Azido-N-[(S)-1-hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-3-phenyl-propionamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (R)-2-Azido-N-[(S)-1-hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-3-phenyl-propionamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-2-Azido-N-[(S)-1-hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-3-phenyl-propionamide

There total 10 articles about (R)-2-Azido-N-[(S)-1-hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-3-phenyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 439296-19-2
(S)-2-Azido-3-phenyl-propionic acid (S)-2-((R)-2-azido-3-phenyl-propionylamino)-3-(4-methoxy-phenyl)-propyl ester

: 439296-18-1
(R)-2-Azido-N-[(S)-1-hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-3-phenyl-propionamide

Guidance literature:: With lithium hydroxide; In methanol; at 20 ℃; for 0.5h;
DOI:10.1016/S0040-4039(02)00133-8

Reference yield: 82.0%

: 118460-00-7
(R)-2-azido-3-phenylpropionic acid

: 20989-19-9,176035-15-7
(2S)-2-amino-3-(4-methoxyphenyl)propan-1-ol

: 439296-18-1
(R)-2-Azido-N-[(S)-1-hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-3-phenyl-propionamide

: 439296-19-2
(S)-2-Azido-3-phenyl-propionic acid (S)-2-((R)-2-azido-3-phenyl-propionylamino)-3-(4-methoxy-phenyl)-propyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 16h;
DOI:10.1016/S0040-4039(02)00133-8

Reference yield:

: 103-26-4,1754-62-7
Methyl cinnamate

: 439296-18-1
(R)-2-Azido-N-[(S)-1-hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-3-phenyl-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / (DHQD)2-PHAL; CH₃SO₂NH₂; K₂CO₃ / K₃Fe(CN)6; OsO₄ / 2-methyl-propan-2-ol; H₂O / 11 h / 0 °C

2: 81 percent / Raney Ni / ethanol / 3 h / Heating

3: Et₃N / CH₂Cl₂ / 4 h / 0 - 20 °C

4: NaN₃ / dimethylformamide / 6 h / 60 °C

5: 94 percent / LiOH / methanol / 1 h / 20 °C

6: 82 percent / DCC; HOBT / CH₂Cl₂ / 16 h / 0 - 20 °C

With lithium hydroxide; sodium azide; methanesulfonamide; nickel; potassium carbonate; benzotriazol-1-ol; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; dicyclohexyl-carbodiimide; osmium(VIII) oxide; potassium hexacyanoferrate(III); In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0040-4039(02)00133-8