ethyl 3-amino-6-benzofuranyl-2-yl-4-phenylthieno[2,3-b]pyridine-2-carboxylate

Base Information

• Chemical Name: ethyl 3-amino-6-benzofuranyl-2-yl-4-phenylthieno[2,3-b]pyridine-2-carboxylate
• CAS No.: 1173187-41-1
• Molecular Formula: C₂₄H₁₈N₂O₃S
• Molecular Weight: 414.485
• Mol file: 1173187-41-1.mol

Synonyms:ethyl 3-amino-6-benzofuranyl-2-yl-4-phenylthieno[2,3-b]pyridine-2-carboxylate

Chemical Property of ethyl 3-amino-6-benzofuranyl-2-yl-4-phenylthieno[2,3-b]pyridine-2-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 3-amino-6-benzofuranyl-2-yl-4-phenylthieno[2,3-b]pyridine-2-carboxylate

There total 1 articles about ethyl 3-amino-6-benzofuranyl-2-yl-4-phenylthieno[2,3-b]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

6-benzofuran-2-yl-4-phenyl-2-sulfanylpyridine-3carbonitrile (1173187-37-5) + chloroacetic acid ethyl ester (105-39-5) → ethyl 3-amino-6-benzofuranyl-2-yl-4-phenylthieno[2,3-b]pyridine-2-carboxylate (1173187-41-1)

Guidance literature:

6-benzofuran-2-yl-4-phenyl-2-sulfanylpyridine-3carbonitrile; With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

chloroacetic acid ethyl ester; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1080/10426500802077630

Reference yield: 90.0%

ethyl 3-amino-6-benzofuranyl-2-yl-4-phenylthieno[2,3-b]pyridine-2-carboxylate (1173187-41-1) → N-amino-(3-amino-6-benzofuran-2-yl-4-phenylthieno[2,3-b]pyridine-2-yl)carboxamide (1173187-44-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Reflux;

DOI:10.1080/10426500802077630

upstream raw materials:

6-benzofuran-2-yl-4-phenyl-2-sulfanylpyridine-3carbonitrile

chloroacetic acid ethyl ester

Downstream raw materials:

N-amino-(3-amino-6-benzofuran-2-yl-4-phenylthieno[2,3-b]pyridine-2-yl)carboxamide