6-benzofuran-2-yl-4-phenyl-2-sulfanylpyridine-3carbonitrile

Base Information

• Chemical Name: 6-benzofuran-2-yl-4-phenyl-2-sulfanylpyridine-3carbonitrile
• CAS No.: 1173187-37-5
• Molecular Formula: C₂₀H₁₂N₂OS
• Molecular Weight: 328.394
• Mol file: 1173187-37-5.mol

Synonyms:6-benzofuran-2-yl-4-phenyl-2-sulfanylpyridine-3carbonitrile

Chemical Property of 6-benzofuran-2-yl-4-phenyl-2-sulfanylpyridine-3carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-benzofuran-2-yl-4-phenyl-2-sulfanylpyridine-3carbonitrile

There total 1 articles about 6-benzofuran-2-yl-4-phenyl-2-sulfanylpyridine-3carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-benzo[d]furan-2-yl-3-phenylprop-2-en-1-one (23618-30-6) + Cyanothioacetamide (7357-70-2) → 6-benzofuran-2-yl-4-phenyl-2-sulfanylpyridine-3carbonitrile (1173187-37-5)

Guidance literature:

With sodium methylate; In methanol; for 7h; Reflux;

DOI:10.1080/10426500802077630

Reference yield: 85.0%

6-benzofuran-2-yl-4-phenyl-2-sulfanylpyridine-3carbonitrile (1173187-37-5) + chloroacetonitrile (107-14-2) → 3-amino-6-benzofuran-2-yl-4-phenylthieno[2,3-b]pyridine-2-carbonitrile (1173187-43-3)

Guidance literature:

6-benzofuran-2-yl-4-phenyl-2-sulfanylpyridine-3carbonitrile; With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

chloroacetonitrile; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1080/10426500802077630

Reference yield: 80.0%

6-benzofuran-2-yl-4-phenyl-2-sulfanylpyridine-3carbonitrile (1173187-37-5) + chloroacetic acid ethyl ester (105-39-5) → ethyl 3-amino-6-benzofuranyl-2-yl-4-phenylthieno[2,3-b]pyridine-2-carboxylate (1173187-41-1)

Guidance literature:

6-benzofuran-2-yl-4-phenyl-2-sulfanylpyridine-3carbonitrile; With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

chloroacetic acid ethyl ester; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1080/10426500802077630

upstream raw materials:

1-benzo[d]furan-2-yl-3-phenylprop-2-en-1-one

Cyanothioacetamide

Downstream raw materials:

3-amino-6-benzofuran-2-yl-4-phenylthieno[2,3-b]pyridine-2-carbonitrile

ethyl 3-amino-6-benzofuranyl-2-yl-4-phenylthieno[2,3-b]pyridine-2-carboxylate

C₂₃H₁₆N₂O₂S

(3-amino-6-benzofuran-2-yl-4-phenylthieno[2,3-b]pyridin-2yl)phenylmethanone