rac-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]cyclobutanone

Base Information

Chemical Name:rac-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]cyclobutanone
CAS No.:1432048-89-9
Molecular Formula:C₁₇H₁₄F₃NO₃
Molecular Weight:337.298
Hs Code.:

Synonyms:rac-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]cyclobutanone

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Chemical Property of rac-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]cyclobutanone

Chemical Property:

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Technology Process of rac-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]cyclobutanone

There total 6 articles about rac-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]cyclobutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1432049-94-9
pyridin-2-yl{2-[4-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}methanol

: 1432048-89-9
rac-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]cyclobutanone

Guidance literature:: With hydrogenchloride; In water; acetone; at 20 ℃;

Reference yield:

: 1432048-71-9
3-hydroxy-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile

: 1432048-89-9
rac-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]cyclobutanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 1.5 h / Reflux

1.2: 20 - 100 °C

2.1: n-butyllithium / hexane; diethyl ether / 0.75 h / Cooling with acetone-dry ice

2.2: 20 °C

3.1: methanol; sodium tetrahydroborate / 20 °C

4.1: hydrogenchloride / water; acetone / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; n-butyllithium; toluene-4-sulfonic acid; In diethyl ether; hexane; water; acetone; toluene;

Reference yield:

: 1432049-98-3
pyridin-2-yl{2-[4-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octan-2-yl}methanone

: 1432048-89-9
rac-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]cyclobutanone

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; sodium tetrahydroborate / 20 °C

2: hydrogenchloride / water; acetone / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; In water; acetone;