2-[4-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octane-2-carbonitrile

Base Information

Chemical Name:2-[4-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octane-2-carbonitrile
CAS No.:1432049-95-0
Molecular Formula:C₁₄H₁₂F₃NO₃
Molecular Weight:299.249
Hs Code.:

Synonyms:2-[4-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octane-2-carbonitrile

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Chemical Property of 2-[4-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octane-2-carbonitrile

Chemical Property:

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Technology Process of 2-[4-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octane-2-carbonitrile

There total 4 articles about 2-[4-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octane-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1432048-72-0
3-oxo-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile

: 107-21-1
ethylene glycol

: 1432049-95-0
2-[4-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octane-2-carbonitrile

Guidance literature:: 3-oxo-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile; ethylene glycol; With toluene-4-sulfonic acid; In toluene; for 1.5h; Reflux;

With trimethyl orthoformate; In toluene; at 20 - 100 ℃; for 4.66667h;

Reference yield:

: 1432048-71-9
3-hydroxy-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile

: 107-21-1
ethylene glycol

: 1432049-95-0
2-[4-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octane-2-carbonitrile

Guidance literature:: 3-hydroxy-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile; ethylene glycol; With toluene-4-sulfonic acid; In toluene; for 1.5h; Reflux;

With trimethyl orthoformate; at 20 - 100 ℃;

Reference yield:

: 49561-96-8
(4-trifluoromethoxy-phenyl)-acetonitrile

: 1432049-95-0
2-[4-(trifluoromethoxy)phenyl]-5,8-dioxaspiro[3.4]octane-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethyl ether; tetrahydrofuran / 1 h / -75 °C

1.2: 1 h / -75 °C

1.3: 20 °C

2.1: toluene-4-sulfonic acid / toluene / 1.5 h / Reflux

2.2: 20 - 100 °C

With toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; toluene;