methyl 2-(((3aR,4S,6R,6aS)-6-(7-(benzyloxy)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate

Base Information

Chemical Name:methyl 2-(((3aR,4S,6R,6aS)-6-(7-(benzyloxy)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate
CAS No.:1431867-56-9
Molecular Formula:C₂₅H₃₁N₅O₆S
Molecular Weight:529.617
Hs Code.:

methyl 2-(((3aR,4S,6R,6aS)-6-(7-(benzyloxy)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate

Synonyms:methyl 2-(((3aR,4S,6R,6aS)-6-(7-(benzyloxy)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate

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Chemical Property of methyl 2-(((3aR,4S,6R,6aS)-6-(7-(benzyloxy)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate

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Technology Process of methyl 2-(((3aR,4S,6R,6aS)-6-(7-(benzyloxy)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate

There total 7 articles about methyl 2-(((3aR,4S,6R,6aS)-6-(7-(benzyloxy)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1431867-47-8
(3aR,4S,6R,6aS)-6-(7-(benzyloxy)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol

: 96-32-2
bromoacetic acid methyl ester

: 1431867-56-9
methyl 2-(((3aR,4S,6R,6aS)-6-(7-(benzyloxy)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate

Guidance literature:: (3aR,4S,6R,6aS)-6-(7-(benzyloxy)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol; With sodium hydride; In tetrahydrofuran; mineral oil; at -10 ℃; for 0.25h;

bromoacetic acid methyl ester; In tetrahydrofuran; mineral oil; at -10 ℃; for 2h;

Reference yield:

: 145783-14-8
4,6-dichloro-5-nitro-2-(propylsulfanyl)pyrimidine

: 1431867-56-9
methyl 2-(((3aR,4S,6R,6aS)-6-(7-(benzyloxy)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: iron; acetic acid / 4 h

2.1: triethylamine / tetrahydrofuran / 24 h / Reflux

3.1: acetic acid; sodium nitrite / 1 h / 20 °C

4.1: potassium carbonate / 88 h / 70 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / -10 °C

5.2: 2 h / -10 °C

With iron; sodium hydride; potassium carbonate; acetic acid; triethylamine; sodium nitrite; In tetrahydrofuran; mineral oil;

Reference yield:

: 145783-15-9
4,6-dichloro-2-(propylsulfanyl)-5-pyrimidinamine

: 1431867-56-9
methyl 2-(((3aR,4S,6R,6aS)-6-(7-(benzyloxy)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 24 h / Reflux

2.1: acetic acid; sodium nitrite / 1 h / 20 °C

3.1: potassium carbonate / 88 h / 70 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / -10 °C

4.2: 2 h / -10 °C

With sodium hydride; potassium carbonate; acetic acid; triethylamine; sodium nitrite; In tetrahydrofuran; mineral oil;