tert-butyl [3-(4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-3-(2,4-dichlorophenyl)thien-2-yl}phenoxy)propyl]carbamate

Base Information

Chemical Name:tert-butyl [3-(4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-3-(2,4-dichlorophenyl)thien-2-yl}phenoxy)propyl]carbamate
CAS No.:1207203-50-6
Molecular Formula:C₃₇H₃₉Cl₂N₃O₅S
Molecular Weight:708.706
Hs Code.:

Synonyms:tert-butyl [3-(4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-3-(2,4-dichlorophenyl)thien-2-yl}phenoxy)propyl]carbamate

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Chemical Property of tert-butyl [3-(4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-3-(2,4-dichlorophenyl)thien-2-yl}phenoxy)propyl]carbamate

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Technology Process of tert-butyl [3-(4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-3-(2,4-dichlorophenyl)thien-2-yl}phenoxy)propyl]carbamate

There total 4 articles about tert-butyl [3-(4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-3-(2,4-dichlorophenyl)thien-2-yl}phenoxy)propyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1207203-48-2
1-{[4-(2,4-Dichlorophenyl)-5-(4-hydroxyphenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

: 83948-53-2
3-bromopropylamine tert-butylcarbamate

: 1207203-50-6
tert-butyl [3-(4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-3-(2,4-dichlorophenyl)thien-2-yl}phenoxy)propyl]carbamate

Guidance literature:: With potassium carbonate; In acetone; for 4h; Reflux;

Reference yield:

: 80139-80-6
4-carbamoyl-4-phenylpiperidine

: 1207203-50-6
tert-butyl [3-(4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-3-(2,4-dichlorophenyl)thien-2-yl}phenoxy)propyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 20 °C

2: boron tribromide / dichloromethane / 20 °C / Cooling with ice

3: potassium carbonate / acetone / 4 h / Reflux

With boron tribromide; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; acetone;

Reference yield:

: 1207203-47-1
4-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)thiophene-2-carboxylic acid

: 1207203-50-6
tert-butyl [3-(4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-3-(2,4-dichlorophenyl)thien-2-yl}phenoxy)propyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 20 °C

2: boron tribromide / dichloromethane / 20 °C / Cooling with ice

3: potassium carbonate / acetone / 4 h / Reflux

With boron tribromide; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; acetone;