5-[3-(3-allyloxybenzyloxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile

Base Information

Chemical Name:5-[3-(3-allyloxybenzyloxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile
CAS No.:931410-21-8
Molecular Formula:C₃₂H₃₆N₂O₂
Molecular Weight:480.65
Hs Code.:

Synonyms:5-[3-(3-allyloxybenzyloxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile

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Chemical Property of 5-[3-(3-allyloxybenzyloxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile

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Technology Process of 5-[3-(3-allyloxybenzyloxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile

There total 4 articles about 5-[3-(3-allyloxybenzyloxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 69411-94-5
1-allyloxy-3-bromomethylbenzene

: 931410-21-8
5-[3-(3-allyloxybenzyloxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile

Guidance literature:: 5-(3-hydroxyazetidin-1-yl)-5-methyl-2,2-diphenylhexanenitrile; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

1-allyloxy-3-bromomethylbenzene; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

With hydrogenchloride; sodium hydrogencarbonate; more than 3 stages;

Reference yield: 54.0%

: 5-(3-hydroxyazetidin-1-yl)-5-methyl-2,2-diphenylhexanenitrile

: 69411-94-5
1-allyloxy-3-bromomethylbenzene

: 931410-21-8
5-[3-(3-allyloxybenzyloxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile

Guidance literature:: 5-(3-hydroxyazetidin-1-yl)-5-methyl-2,2-diphenylhexanenitrile; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere;

1-allyloxy-3-bromomethylbenzene; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm200884j

Reference yield:

: 1355532-89-6
5-amino-5-methyl-2,2-diphenyl-hexanenitrile hydrochloride

: 931410-21-8
5-[3-(3-allyloxybenzyloxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / dichloromethane; water

1.2: 18 h / 70 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 0 °C / Inert atmosphere

With sodium hydride; sodium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm200884j