1-[2-(4-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

Base Information

• Chemical Name: 1-[2-(4-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane
• CAS No.: 1370451-34-5
• Molecular Formula: C₂₂H₃₄N₆O₁₀S
• Molecular Weight: 574.612
• Mol file: 1370451-34-5.mol

Synonyms:1-[2-(4-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

Chemical Property of 1-[2-(4-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-(4-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

There total 4 articles about 1-[2-(4-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-nitro-benzenesulfonyl)-aziridine (43090-97-7) + tris(tert-butyl) 2,2',2''-(1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate hydrobromide → 1-[2-(4-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane (1370451-34-5)

Guidance literature:

1-(4-nitro-benzenesulfonyl)-aziridine; tris(tert-butyl) 2,2',2''-(1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate hydrobromide; With sodium carbonate; In acetonitrile; for 5h; Inert atmosphere; Reflux;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2012.02.071

Reference yield:

N-(2-hydroxyethyl)-4-nitrobenzenesulfonamide (18226-05-6) → 1-[2-(4-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane (1370451-34-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: potassium hydroxide / water; toluene / 0.5 h / 20 °C

3.1: sodium carbonate / acetonitrile / 5 h / Inert atmosphere; Reflux

3.2: 3 h / 20 °C

With sodium carbonate; triethylamine; potassium hydroxide; In dichloromethane; water; toluene; acetonitrile;

DOI:10.1016/j.bmcl.2012.02.071

Reference yield:

2-(4-nitrophenylsulfonylamino)ethyl methanesulfonate (1370451-29-8) → 1-[2-(4-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane (1370451-34-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / water; toluene / 0.5 h / 20 °C

2.1: sodium carbonate / acetonitrile / 5 h / Inert atmosphere; Reflux

2.2: 3 h / 20 °C

With sodium carbonate; potassium hydroxide; In water; toluene; acetonitrile;

DOI:10.1016/j.bmcl.2012.02.071

upstream raw materials:

2-(4-nitrophenylsulfonylamino)ethyl methanesulfonate

1-(4-nitro-benzenesulfonyl)-aziridine

N-(2-hydroxyethyl)-4-nitrobenzenesulfonamide

4-Nitrobenzenesulfonyl chloride