2-(4-nitrophenylsulfonylamino)ethyl methanesulfonate

Base Information

• Chemical Name: 2-(4-nitrophenylsulfonylamino)ethyl methanesulfonate
• CAS No.: 1370451-29-8
• Molecular Formula: C₉H₁₂N₂O₇S₂
• Molecular Weight: 324.335
• Mol file: 1370451-29-8.mol

Synonyms:2-(4-nitrophenylsulfonylamino)ethyl methanesulfonate

Chemical Property of 2-(4-nitrophenylsulfonylamino)ethyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(4-nitrophenylsulfonylamino)ethyl methanesulfonate

There total 2 articles about 2-(4-nitrophenylsulfonylamino)ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-(2-hydroxyethyl)-4-nitrobenzenesulfonamide (18226-05-6) + methanesulfonyl chloride (124-63-0) → 2-(4-nitrophenylsulfonylamino)ethyl methanesulfonate (1370451-29-8)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1002/cmdc.202000950

Reference yield:

4-Nitrobenzenesulfonyl chloride (98-74-8) → 2-(4-nitrophenylsulfonylamino)ethyl methanesulfonate (1370451-29-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2012.02.071

Reference yield: 46.0%

2-(4-nitrophenylsulfonylamino)ethyl methanesulfonate (1370451-29-8) + propan-1-ol-3-amine (156-87-6) → N-(2-((3-hydroxypropyl)amino)ethyl)-4-nitrobenzenesulfonamide

Guidance literature:

With pyridine; In acetonitrile; at 80 ℃; for 24h;

DOI:10.1002/cmdc.202000950

upstream raw materials:

N-(2-hydroxyethyl)-4-nitrobenzenesulfonamide

methanesulfonyl chloride

4-Nitrobenzenesulfonyl chloride

Downstream raw materials:

1-[2-(4-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

1-[2-(4-aminophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

1-(4-nitro-benzenesulfonyl)-aziridine