(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-phenyl-N-acetylpyrazoline

Base Information

Chemical Name:(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-phenyl-N-acetylpyrazoline
CAS No.:875014-37-2
Molecular Formula:C₂₈H₃₆N₂O₂
Molecular Weight:432.606
Hs Code.:

Synonyms:(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-phenyl-N-acetylpyrazoline

Suppliers and Price of (16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-phenyl-N-acetylpyrazoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-phenyl-N-acetylpyrazoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-phenyl-N-acetylpyrazoline

There total 5 articles about (16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-phenyl-N-acetylpyrazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 875014-36-1
(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-phenylpyrazoline

: 75-36-5
acetyl chloride

: 875014-37-2
(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-phenyl-N-acetylpyrazoline

Guidance literature:: at 20 ℃;
DOI:10.1016/j.bmc.2005.08.024

Reference yield:

: 303128-58-7
(16E)-16-benzyliden-3β-hydroxyl-5α-androstan-17-one

: 875014-37-2
(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-phenyl-N-acetylpyrazoline

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 5 h / Heating

2: 55 percent / dimethylsulfoxide; trifluoroacetic acid; dicyclohexylcarbodiimide / pyridine / benzene / 20 °C

3: 68 percent / 20 °C

With hydrazine hydrate; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; pyridine; In ethanol; benzene; 2: Moffat oxidation;
DOI:10.1016/j.bmc.2005.08.024

Reference yield:

: 875014-32-7
(8β,9α,14α)-3β-(trifluoroacetoxy)-16(E)-(phenylmethylene)-5α-androstan-17-one

: 875014-37-2
(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-phenyl-N-acetylpyrazoline

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / hydrazine hydrate / 7 h / Heating

2: potassium hydroxide / Heating

3: 55 percent / dimethylsulfoxide; trifluoroacetic acid; dicyclohexylcarbodiimide / pyridine / benzene / 20 °C

4: 68 percent / 20 °C

With potassium hydroxide; hydrazine hydrate; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; pyridine; In benzene; 3: Moffat oxidation;
DOI:10.1016/j.bmc.2005.08.024