5-benzyl-8(R)--9(R)-phenyl-4,7-dioxo-3,6-diaza-11-benzena-10-oxacycloundecaphane

Base Information

Chemical Name:5-benzyl-8(R)--9(R)-phenyl-4,7-dioxo-3,6-diaza-11-benzena-10-oxacycloundecaphane
CAS No.:127086-91-3
Molecular Formula:C₃₅H₃₅N₃O₅
Molecular Weight:577.68
Hs Code.:

5-benzyl-8(R)-<N-(carbobenzyloxy)-N-methylamino>-9(R)-phenyl-4,7-dioxo-3,6-diaza-11-benzena-10-oxacycloundecaphane

Synonyms:5-benzyl-8(R)--9(R)-phenyl-4,7-dioxo-3,6-diaza-11-benzena-10-oxacycloundecaphane

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Chemical Property of 5-benzyl-8(R)--9(R)-phenyl-4,7-dioxo-3,6-diaza-11-benzena-10-oxacycloundecaphane

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Technology Process of 5-benzyl-8(R)--9(R)-phenyl-4,7-dioxo-3,6-diaza-11-benzena-10-oxacycloundecaphane

There total 17 articles about 5-benzyl-8(R)--9(R)-phenyl-4,7-dioxo-3,6-diaza-11-benzena-10-oxacycloundecaphane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 127102-45-8
1-benzyl-2-(tert-butyloxycarbonyl)-8(R)--7(R)-phenyl-2-aza-5(1,4)-benzena-6-oxa-1(2,5)-oxazolacyclooctaphane

: 127086-91-3
5-benzyl-8(R)--9(R)-phenyl-4,7-dioxo-3,6-diaza-11-benzena-10-oxacycloundecaphane

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 96h; Ambient temperature;
DOI:10.1021/ja00175a039

Reference yield:

: 156-38-7
4-hydroxyphenylacetate

: 127086-91-3
5-benzyl-8(R)--9(R)-phenyl-4,7-dioxo-3,6-diaza-11-benzena-10-oxacycloundecaphane

Guidance literature:: Multi-step reaction with 11 steps

1: 97 percent / conc. H₂SO₄ / Heating

2: 90 percent / diethylazodicarboxylate, PPh₃ / tetrahydrofuran / Ambient temperature

3: 99 percent / trifluoracetic acid / CH₂Cl₂ / Ambient temperature

4: 3.63 g / NaIO₄, RuCl₃ dihydrate / acetonitrile; CCl₄; H₂O / 2 h / 0 °C

5: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, 0 deg C, 2.) 0 deg C, 4 h

6: 93 percent / trifluoroacetic acid / CH₂Cl₂ / 0 - 20 °C

7: 81 percent / DMAP, N-methylmorpholine / tetrahydrofuran / Ambient temperature

8: 89 percent / LiAlH₄ / tetrahydrofuran / 0.25 h / 0 °C

9: 82 percent / pyridine, DMAP / CH₂Cl₂ / 0 °C

10: 76 percent / NaH / tetrahydrofuran / 48 h

11: 72 percent / trifluoroacetic acid / CH₂Cl₂ / 96 h / Ambient temperature

With 4-methyl-morpholine; pyridine; dmap; ruthenium trichloride; sodium periodate; lithium aluminium tetrahydride; sulfuric acid; sodium hydride; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; isobutyl chloroformate; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/ja00175a039

Reference yield:

: 41997-33-5
iso-propyl 4-hydroxyphenylacetate

: 127086-91-3
5-benzyl-8(R)--9(R)-phenyl-4,7-dioxo-3,6-diaza-11-benzena-10-oxacycloundecaphane

Guidance literature:: Multi-step reaction with 10 steps

1: 90 percent / diethylazodicarboxylate, PPh₃ / tetrahydrofuran / Ambient temperature

2: 99 percent / trifluoracetic acid / CH₂Cl₂ / Ambient temperature

3: 3.63 g / NaIO₄, RuCl₃ dihydrate / acetonitrile; CCl₄; H₂O / 2 h / 0 °C

4: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, 0 deg C, 2.) 0 deg C, 4 h

5: 93 percent / trifluoroacetic acid / CH₂Cl₂ / 0 - 20 °C

6: 81 percent / DMAP, N-methylmorpholine / tetrahydrofuran / Ambient temperature

7: 89 percent / LiAlH₄ / tetrahydrofuran / 0.25 h / 0 °C

8: 82 percent / pyridine, DMAP / CH₂Cl₂ / 0 °C

9: 76 percent / NaH / tetrahydrofuran / 48 h

10: 72 percent / trifluoroacetic acid / CH₂Cl₂ / 96 h / Ambient temperature

With 4-methyl-morpholine; pyridine; dmap; ruthenium trichloride; sodium periodate; lithium aluminium tetrahydride; sodium hydride; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; isobutyl chloroformate; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/ja00175a039