{3-(4-{[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}piperidin-1-yl)-1-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}acetonitrile

Base Information

Chemical Name:{3-(4-{[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}piperidin-1-yl)-1-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}acetonitrile
CAS No.:1379375-94-6
Molecular Formula:C₄₉H₅₉F₃N₈O₃Si₂
Molecular Weight:921.225
Hs Code.:

{3-(4-{[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}piperidin-1-yl)-1-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}acetonitrile

Synonyms:{3-(4-{[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}piperidin-1-yl)-1-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}acetonitrile

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Chemical Property of {3-(4-{[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}piperidin-1-yl)-1-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}acetonitrile

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Technology Process of {3-(4-{[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}piperidin-1-yl)-1-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}acetonitrile

There total 8 articles about {3-(4-{[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}piperidin-1-yl)-1-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1379375-11-7
{3-oxo-1-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}acetonitrile

: 1379375-93-5
4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-(piperidin-4-yloxy)-6-(trifluoromethyl)pyridine

: 1379375-94-6
{3-(4-{[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}piperidin-1-yl)-1-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}acetonitrile

Guidance literature:: With sodium cyanoborohydride; zinc(II) chloride; In methanol;

Reference yield:

: 1196157-41-1
[2-chloro-6-(trifluoromethyl)pyridin-4-yl]methanol

: 1379375-94-6
{3-(4-{[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}piperidin-1-yl)-1-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole; dmap / dichloromethane / 64 h / 0 - 20 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h

3: hydrogenchloride / 1,4-dioxane / 3 h

4: sodium cyanoborohydride; zinc(II) chloride / methanol

With 1H-imidazole; hydrogenchloride; dmap; sodium hydride; sodium cyanoborohydride; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; mineral oil;

Reference yield:

: 1196154-43-4
ethyl 2-chloro-6-(trifluoromethyl)isonicotinate

: 1379375-94-6
{3-(4-{[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}piperidin-1-yl)-1-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / ethanol / 3 h / 0 - 20 °C

2: 1H-imidazole; dmap / dichloromethane / 64 h / 0 - 20 °C

3: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h

4: hydrogenchloride / 1,4-dioxane / 3 h

5: sodium cyanoborohydride; zinc(II) chloride / methanol

With 1H-imidazole; hydrogenchloride; dmap; sodium tetrahydroborate; sodium hydride; sodium cyanoborohydride; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; mineral oil;