2-CHLORO-6-TRIFLUOROMETHYL-ISONICOTINIC ACID ETHYL ESTER

Base Information

Chemical Name:2-CHLORO-6-TRIFLUOROMETHYL-ISONICOTINIC ACID ETHYL ESTER
CAS No.:1196154-43-4
Molecular Formula:C₉H₇ClF₃NO₂
Molecular Weight:253.608
Hs Code.:
Mol file:1196154-43-4.mol

Synonyms:2-CHLORO-6-TRIFLUOROMETHYL-ISONICOTINIC ACID ETHYL ESTER;Ethyl 2-chloro-6-(trifluoromethyl)pyridine-4-carboxylate;Ethyl 2-chloro-6-(trifluoromethyl)isonicotinate

Suppliers and Price of 2-CHLORO-6-TRIFLUOROMETHYL-ISONICOTINIC ACID ETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl2-chloro-6-(trifluoromethyl)isonicotinate 97%
5g
$ 1409.00

Crysdot
Ethyl2-chloro-6-(trifluoromethyl)isonicotinate 97%
1g
$ 541.00

Ambeed
Ethyl2-chloro-6-(trifluoromethyl)isonicotinate 95%
1g
$ 352.00

Ambeed
Ethyl2-chloro-6-(trifluoromethyl)isonicotinate 95%
250mg
$ 139.00

Ambeed
Ethyl2-chloro-6-(trifluoromethyl)isonicotinate 95%
100mg
$ 90.00

Total 8 raw suppliers

Chemical Property of 2-CHLORO-6-TRIFLUOROMETHYL-ISONICOTINIC ACID ETHYL ESTER

Chemical Property:

Boiling Point:263.2±40.0 °C(Predicted)
PKA:-5.55±0.10(Predicted)
PSA：39.19000
Density:1.389±0.06 g/cm3(Predicted)
LogP:2.93050
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl2-chloro-6-(trifluoromethyl)isonicotinate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-6-TRIFLUOROMETHYL-ISONICOTINIC ACID ETHYL ESTER

There total 1 articles about 2-CHLORO-6-TRIFLUOROMETHYL-ISONICOTINIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122-51-0
orthoformic acid triethyl ester

: 280566-45-2
2-chloro-6-(trifluoromethyl)pyridine-3-carboxylic acid

: 796090-23-8
2-chloro-6-(trifluoromethyl)pyridine-4-carboxylic acid

: 1214346-14-1
ethyl 2-chloro-6-(trifluoromethyl)nicotinate

: 1196154-43-4
ethyl 2-chloro-6-(trifluoromethyl)isonicotinate

Guidance literature:: at 120 ℃; for 5h;

Reference yield:

: 1196154-43-4
ethyl 2-chloro-6-(trifluoromethyl)isonicotinate

: 1379375-91-3
4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-chloro-6-(trifluoromethyl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 3 h / 0 - 20 °C

2: 1H-imidazole / dmap / dichloromethane / 64 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; dmap; In ethanol; dichloromethane;

Reference yield:

: 1196154-43-4
ethyl 2-chloro-6-(trifluoromethyl)isonicotinate

: 1379375-92-4
tert-butyl 4-{[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / ethanol / 3 h / 0 - 20 °C

2: 1H-imidazole / dmap / dichloromethane / 64 h / 20 °C

3: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h

With 1H-imidazole; sodium tetrahydroborate; sodium hydride; dmap; In tetrahydrofuran; ethanol; dichloromethane; mineral oil;