4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-(piperidin-4-yloxy)-6-(trifluoromethyl)pyridine

Base Information

Chemical Name:4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-(piperidin-4-yloxy)-6-(trifluoromethyl)pyridine
CAS No.:1379375-93-5
Molecular Formula:C₂₈H₃₃F₃N₂O₂Si
Molecular Weight:514.663
Hs Code.:

Synonyms:4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-(piperidin-4-yloxy)-6-(trifluoromethyl)pyridine

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Chemical Property of 4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-(piperidin-4-yloxy)-6-(trifluoromethyl)pyridine

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Technology Process of 4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-(piperidin-4-yloxy)-6-(trifluoromethyl)pyridine

There total 6 articles about 4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-(piperidin-4-yloxy)-6-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1379375-92-4
tert-butyl 4-{[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}piperidine-1-carboxylate

: 1379375-93-5
4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-(piperidin-4-yloxy)-6-(trifluoromethyl)pyridine

Guidance literature:: tert-butyl 4-{[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}piperidine-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; for 3h;

With sodium hydrogencarbonate; In 1,4-dioxane; water; pH=7 - 8;

Reference yield:

: 1196157-41-1
[2-chloro-6-(trifluoromethyl)pyridin-4-yl]methanol

: 1379375-93-5
4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-(piperidin-4-yloxy)-6-(trifluoromethyl)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / dmap / dichloromethane / 64 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h

3.1: hydrogenchloride / 1,4-dioxane / 3 h

3.2: pH 7 - 8

With 1H-imidazole; hydrogenchloride; sodium hydride; dmap; In tetrahydrofuran; 1,4-dioxane; dichloromethane; mineral oil;

Reference yield:

: 1196154-43-4
ethyl 2-chloro-6-(trifluoromethyl)isonicotinate

: 1379375-93-5
4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-(piperidin-4-yloxy)-6-(trifluoromethyl)pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / ethanol / 3 h / 0 - 20 °C

2.1: 1H-imidazole / dmap / dichloromethane / 64 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h

4.1: hydrogenchloride / 1,4-dioxane / 3 h

4.2: pH 7 - 8

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; sodium hydride; dmap; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; mineral oil;