(5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-(pyrimidin-2-yl)phenyl)methanone

Base Information

Chemical Name:(5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-(pyrimidin-2-yl)phenyl)methanone
CAS No.:1262395-87-8
Molecular Formula:C₂₄H₂₄ClN₅O
Molecular Weight:433.94
Hs Code.:

Synonyms:(5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-(pyrimidin-2-yl)phenyl)methanone

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Chemical Property of (5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-(pyrimidin-2-yl)phenyl)methanone

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Technology Process of (5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-(pyrimidin-2-yl)phenyl)methanone

There total 9 articles about (5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-(pyrimidin-2-yl)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1262396-90-6
(5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-iodophenyl)methanone

: 153435-63-3
2-(tributylstannyl)pyrimidine

: 1262395-87-8
(5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-(pyrimidin-2-yl)phenyl)methanone

Guidance literature:: With cesium fluoride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 130 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 1262396-27-9
4-methylene-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

: 1262395-87-8
(5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-(pyrimidin-2-yl)phenyl)methanone

Guidance literature:: Multi-step reaction with 9 steps

1: diethyl ether; tetrahydrofuran

2: hydrogen / Pd-BaSO₄ / methanol / 20 °C

3: borane-THF / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: TEMPO; BAIB / dichloromethane / 2 h / 25 °C

5: acetic acid / 1,1-dichloroethane / 20 °C

6: sodium tris(acetoxy)borohydride / 1,1-dichloroethane; acetic acid / 18 h / 20 °C

7: trifluoroacetic acid / dichloromethane / 0 - 20 °C

8: triethylamine / dichloromethane / 0 °C

9: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / 130 °C / Microwave irradiation

With borane-THF; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; cesium fluoride; trifluoroacetic acid; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Pd-BaSO₄; In tetrahydrofuran; methanol; diethyl ether; 1,1-dichloroethane; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1262396-30-4
6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-5(S)-carboxylic acid benzyl ester

: 1262395-87-8
(5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-(pyrimidin-2-yl)phenyl)methanone

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogen / Pd-BaSO₄ / methanol / 20 °C

2: borane-THF / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: TEMPO; BAIB / dichloromethane / 2 h / 25 °C

4: acetic acid / 1,1-dichloroethane / 20 °C

5: sodium tris(acetoxy)borohydride / 1,1-dichloroethane; acetic acid / 18 h / 20 °C

6: trifluoroacetic acid / dichloromethane / 0 - 20 °C

7: triethylamine / dichloromethane / 0 °C

8: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / 130 °C / Microwave irradiation

With borane-THF; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; cesium fluoride; trifluoroacetic acid; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Pd-BaSO₄; In tetrahydrofuran; methanol; 1,1-dichloroethane; dichloromethane; acetic acid; N,N-dimethyl-formamide;