4-methylene-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

Base Information

Chemical Name:4-methylene-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester
CAS No.:1262396-27-9
Molecular Formula:C₁₉H₂₅NO₄
Molecular Weight:331.412
Hs Code.:

Synonyms:4-methylene-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

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Chemical Property of 4-methylene-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

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Technology Process of 4-methylene-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

There total 1 articles about 4-methylene-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.4%

: 1262396-25-7
4-oxo-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

: 1779-49-3
Methyltriphenylphosphonium bromide

: 1262396-27-9
4-methylene-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

Guidance literature:: Methyltriphenylphosphonium bromide; With sodium hexamethyldisilazane; In toluene; at 0 - 20 ℃;

4-oxo-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester; In toluene; at 0 - 20 ℃;

Reference yield: 88.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 1262396-27-9
4-methylene-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

: 1262396-30-4
6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-5(S)-carboxylic acid benzyl ester

Guidance literature:: In tetrahydrofuran; diethyl ether;

Reference yield:

: 1262396-27-9
4-methylene-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

: 1262396-90-6
(5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-iodophenyl)methanone

Guidance literature:: Multi-step reaction with 8 steps

1: diethyl ether; tetrahydrofuran

2: hydrogen / Pd-BaSO₄ / methanol / 20 °C

3: borane-THF / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: TEMPO; BAIB / dichloromethane / 2 h / 25 °C

5: acetic acid / 1,1-dichloroethane / 20 °C

6: sodium tris(acetoxy)borohydride / 1,1-dichloroethane; acetic acid / 18 h / 20 °C

7: trifluoroacetic acid / dichloromethane / 0 - 20 °C

8: triethylamine / dichloromethane / 0 °C

With borane-THF; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; trifluoroacetic acid; Pd-BaSO₄; In tetrahydrofuran; methanol; diethyl ether; 1,1-dichloroethane; dichloromethane; acetic acid;