(5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-iodophenyl)methanone

Base Information

Chemical Name:(5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-iodophenyl)methanone
CAS No.:1262396-90-6
Molecular Formula:C₂₀H₂₁ClIN₃O
Molecular Weight:481.764
Hs Code.:

Synonyms:(5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-iodophenyl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-iodophenyl)methanone

Chemical Property:

Boiling Point:611.6±45.0 °C(Predicted)
Density:1.63±0.1 g/cm3(Predicted)

Purity/Quality:

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Technology Process of (5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-iodophenyl)methanone

There total 8 articles about (5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-iodophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 609-67-6
2-Iodobenzoyl chloride

: 1262396-67-7
(S)-N-(6-azaspiro[2.5]octan-5-ylmethyl)-5-chloropyridin-2-amine

: 1262396-90-6
(5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-iodophenyl)methanone

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;

Reference yield:

: 1262396-27-9
4-methylene-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

: 1262396-90-6
(5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-iodophenyl)methanone

Guidance literature:: Multi-step reaction with 8 steps

1: diethyl ether; tetrahydrofuran

2: hydrogen / Pd-BaSO₄ / methanol / 20 °C

3: borane-THF / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: TEMPO; BAIB / dichloromethane / 2 h / 25 °C

5: acetic acid / 1,1-dichloroethane / 20 °C

6: sodium tris(acetoxy)borohydride / 1,1-dichloroethane; acetic acid / 18 h / 20 °C

7: trifluoroacetic acid / dichloromethane / 0 - 20 °C

8: triethylamine / dichloromethane / 0 °C

With borane-THF; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; trifluoroacetic acid; Pd-BaSO₄; In tetrahydrofuran; methanol; diethyl ether; 1,1-dichloroethane; dichloromethane; acetic acid;

Reference yield:

: 1262396-30-4
6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-5(S)-carboxylic acid benzyl ester

: 1262396-90-6
(5(S)-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-iodophenyl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen / Pd-BaSO₄ / methanol / 20 °C

2: borane-THF / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: TEMPO; BAIB / dichloromethane / 2 h / 25 °C

4: acetic acid / 1,1-dichloroethane / 20 °C

5: sodium tris(acetoxy)borohydride / 1,1-dichloroethane; acetic acid / 18 h / 20 °C

6: trifluoroacetic acid / dichloromethane / 0 - 20 °C

7: triethylamine / dichloromethane / 0 °C

With borane-THF; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; trifluoroacetic acid; Pd-BaSO₄; In tetrahydrofuran; methanol; 1,1-dichloroethane; dichloromethane; acetic acid;