ethyl 3-(2-{[3-chloro-5-(4-morpholinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

Base Information

Chemical Name:ethyl 3-(2-{[3-chloro-5-(4-morpholinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate
CAS No.:1095274-35-3
Molecular Formula:C₁₆H₂₀ClN₃O₅
Molecular Weight:369.805
Hs Code.:

Synonyms:ethyl 3-(2-{[3-chloro-5-(4-morpholinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

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Chemical Property of ethyl 3-(2-{[3-chloro-5-(4-morpholinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

Chemical Property:

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Technology Process of ethyl 3-(2-{[3-chloro-5-(4-morpholinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

There total 5 articles about ethyl 3-(2-{[3-chloro-5-(4-morpholinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095274-34-2
3-chloro-5-(4-morpholinyl)benzohydrazide

: 36239-09-5
ethyl chlorocarbonylacetate

: 1095274-35-3
ethyl 3-(2-{[3-chloro-5-(4-morpholinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2010.01.012

Reference yield:

: 327056-73-5
3-fluoro-5-chlorobenzonitrile

: 1095274-35-3
ethyl 3-(2-{[3-chloro-5-(4-morpholinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / dimethyl sulfoxide / 20 - 80 °C

2.1: sodium hydroxide / ethanol; water / Heating / reflux

2.2: pH 5 - 6

3.1: sulfuric acid / 4 h

3.2: 20 °C / pH 7

4.1: hydrazine / ethanol / 4 h / Heating / reflux

5.1: tetrahydrofuran / 0.5 h / 20 °C

With sodium hydroxide; potassium carbonate; hydrazine; sulfuric acid; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;

Reference yield:

: 1095274-32-0
3-chloro-5-(4-morpholinyl)benzoic acid

: 1095274-35-3
ethyl 3-(2-{[3-chloro-5-(4-morpholinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 4 h

1.2: 20 °C / pH 7

2.1: hydrazine / ethanol / 4 h / Heating / reflux

3.1: tetrahydrofuran / 0.5 h / 20 °C

With hydrazine; sulfuric acid; In tetrahydrofuran; ethanol;