2-(4-amino-3-chlorophenyl)-4-methoxybenzothiazole

Base Information

Chemical Name:2-(4-amino-3-chlorophenyl)-4-methoxybenzothiazole
CAS No.:247080-52-0
Molecular Formula:C₁₄H₁₁ClN₂OS
Molecular Weight:290.773
Hs Code.:

Synonyms:2-(4-amino-3-chlorophenyl)-4-methoxybenzothiazole

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Chemical Property of 2-(4-amino-3-chlorophenyl)-4-methoxybenzothiazole

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Technology Process of 2-(4-amino-3-chlorophenyl)-4-methoxybenzothiazole

There total 7 articles about 2-(4-amino-3-chlorophenyl)-4-methoxybenzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 247080-34-8
2-(4-amino-3-iodophenyl)-4-methoxybenzothiazole

: 247080-52-0
2-(4-amino-3-chlorophenyl)-4-methoxybenzothiazole

Guidance literature:: With copper(l) chloride; In N,N-dimethyl-formamide; for 15h; Heating;
DOI:10.1021/jm990104o

Reference yield:

: 24367-70-2
N-(2-methoxyphenyl)-4-nitrothiobenzamide

: 247080-52-0
2-(4-amino-3-chlorophenyl)-4-methoxybenzothiazole

Guidance literature:: Multi-step reaction with 4 steps

1: 68 percent / potassium ferricyanide; aq. NaOH / ethanol / 0.5 h / 90 °C

2: 72 percent / SnCl₂*2H₂O / ethanol / 2 h / Heating

3: 30 percent / ICl; AcOH / 2 h / 25 °C

4: 34 percent / CuCl / dimethylformamide / 15 h / Heating

With sodium hydroxide; Iodine monochloride; acetic acid; copper(l) chloride; tin(ll) chloride; potassium hexacyanoferrate(III); In ethanol; N,N-dimethyl-formamide; 1: Jacobson cyclization / 2: Reduction / 3: Iodination / 4: Substitution;
DOI:10.1021/jm990104o

Reference yield:

: 24367-68-8
N-(2-methoxyphenyl)-4-nitrobenzamide

: 247080-52-0
2-(4-amino-3-chlorophenyl)-4-methoxybenzothiazole

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / Lawesson's reagent; HMPA / 6 h / 100 °C

2: 68 percent / potassium ferricyanide; aq. NaOH / ethanol / 0.5 h / 90 °C

3: 72 percent / SnCl₂*2H₂O / ethanol / 2 h / Heating

4: 30 percent / ICl; AcOH / 2 h / 25 °C

5: 34 percent / CuCl / dimethylformamide / 15 h / Heating

With Lawessons reagent; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; Iodine monochloride; acetic acid; copper(l) chloride; tin(ll) chloride; potassium hexacyanoferrate(III); In ethanol; N,N-dimethyl-formamide; 1: Substitution / 2: Jacobson cyclization / 3: Reduction / 4: Iodination / 5: Substitution;
DOI:10.1021/jm990104o