(R)-1-((S)-1-(4-(6-methoxy-2-(4-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

Base Information

Chemical Name:(R)-1-((S)-1-(4-(6-methoxy-2-(4-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine
CAS No.:1352547-07-9
Molecular Formula:C₃₁H₃₅NO₃
Molecular Weight:469.624
Hs Code.:

Synonyms:(R)-1-((S)-1-(4-(6-methoxy-2-(4-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-((S)-1-(4-(6-methoxy-2-(4-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-1-((S)-1-(4-(6-methoxy-2-(4-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

There total 9 articles about (R)-1-((S)-1-(4-(6-methoxy-2-(4-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352547-04-6
3-(4-iodophenyl)-6-methoxy-2-(4-methoxyphenyl)-1H-indene

: 620627-27-2
(S)-2-((R)-3-methylpyrrolidin-1-yl)propan-1-ol

: 1352547-07-9
(R)-1-((S)-1-(4-(6-methoxy-2-(4-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

Guidance literature:: With potassium carbonate; [2,2]bipyridinyl; copper(l) iodide; In m-xylene; at 140 ℃; for 14h; Inert atmosphere;

Reference yield:

: 1711-02-0
4-iodobenzoic acid chloride

: 1352547-07-9
(R)-1-((S)-1-(4-(6-methoxy-2-(4-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / toluene; water / 2.83 h / 0 °C

2.1: 2-methyltetrahydrofuran / 5.25 h / 0 - 5 °C / Inert atmosphere

3.1: potassium hexamethylsilazane / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere

3.2: 60 h

4.1: methanesulfonic acid / dichloromethane / 5 h / 0 - 20 °C

5.1: potassium carbonate / [2,2]bipyridinyl; copper(l) iodide / m-xylene / 14 h / 140 °C / Inert atmosphere

With methanesulfonic acid; potassium hexamethylsilazane; sodium carbonate; potassium carbonate; [2,2]bipyridinyl; copper(l) iodide; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; water; m-xylene; toluene; 5.1: Ullmann Condensation;

Reference yield:

: 22644-27-5
(R)-methylsuccinic acid dimethyl ester

: 1352547-07-9
(R)-1-((S)-1-(4-(6-methoxy-2-(4-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere

1.2: 3 h / 20 °C

2.1: triethylamine / dichloromethane / 1.5 h / -20 - -15 °C

3.1: 24 h / 20 °C / Neat (no solvent)

4.1: potassium carbonate / [2,2]bipyridinyl; copper(l) iodide / m-xylene / 14 h / 140 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; [2,2]bipyridinyl; copper(l) iodide; In tetrahydrofuran; dichloromethane; m-xylene; 4.1: Ullmann Condensation;