5-(3,4-di-tert-butyldimethylsilyloxyphenyl)-1-(2,4,6-trimethylphenylsulfonyl)-5-hexen-2-one

Base Information

Chemical Name:5-(3,4-di-tert-butyldimethylsilyloxyphenyl)-1-(2,4,6-trimethylphenylsulfonyl)-5-hexen-2-one
CAS No.:907195-94-2
Molecular Formula:C₃₃H₅₂O₅SSi₂
Molecular Weight:617.01
Hs Code.:

Synonyms:5-(3,4-di-tert-butyldimethylsilyloxyphenyl)-1-(2,4,6-trimethylphenylsulfonyl)-5-hexen-2-one

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Chemical Property of 5-(3,4-di-tert-butyldimethylsilyloxyphenyl)-1-(2,4,6-trimethylphenylsulfonyl)-5-hexen-2-one

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Technology Process of 5-(3,4-di-tert-butyldimethylsilyloxyphenyl)-1-(2,4,6-trimethylphenylsulfonyl)-5-hexen-2-one

There total 5 articles about 5-(3,4-di-tert-butyldimethylsilyloxyphenyl)-1-(2,4,6-trimethylphenylsulfonyl)-5-hexen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 907195-93-1
ethyl 4-(3,4-di-tert-butyldimethylsilyloxyphenyl)-4-pentenoate

: 6462-31-3
methyl 2,4,6-trimethylphenyl sulfone

: 907195-94-2
5-(3,4-di-tert-butyldimethylsilyloxyphenyl)-1-(2,4,6-trimethylphenylsulfonyl)-5-hexen-2-one

Guidance literature:: methyl 2,4,6-trimethylphenyl sulfone; With n-butyllithium; In tetrahydrofuran; at 20 ℃; for 1h;

ethyl 4-(3,4-di-tert-butyldimethylsilyloxyphenyl)-4-pentenoate; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1002/adsc.200505173

Reference yield:

: 1108192-19-3
((4-bromo-1,2-phenylene)bis(oxy))bis(tert-butyldimethylsilane)

: 907195-94-2
5-(3,4-di-tert-butyldimethylsilyloxyphenyl)-1-(2,4,6-trimethylphenylsulfonyl)-5-hexen-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi; B(OMe)3 / tetrahydrofuran / 20 °C

1.2: acid / tetrahydrofuran

2.1: 99 percent / P(o-tol)3; Ba(OH)2*8H₂O / Pd(OAc)2 / 1,2-dimethoxy-ethane; H₂O / 50 °C

3.1: n-BuLi / tetrahydrofuran / 1 h / 20 °C

3.2: 81 percent / tetrahydrofuran / 1 h / 0 °C

With barium dihydroxide; n-butyllithium; Trimethyl borate; tris-(o-tolyl)phosphine; palladium diacetate; In tetrahydrofuran; 1,2-dimethoxyethane; water; 2.1: Suzuki-Miyaura coupling;
DOI:10.1002/adsc.200505173

Reference yield:

: 907195-92-0
(3,4-bis((tert-butyldimethylsilyl)oxy)phenyl)boronic acid

: 907195-94-2
5-(3,4-di-tert-butyldimethylsilyloxyphenyl)-1-(2,4,6-trimethylphenylsulfonyl)-5-hexen-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / P(o-tol)3; Ba(OH)2*8H₂O / Pd(OAc)2 / 1,2-dimethoxy-ethane; H₂O / 50 °C

2.1: n-BuLi / tetrahydrofuran / 1 h / 20 °C

2.2: 81 percent / tetrahydrofuran / 1 h / 0 °C

With barium dihydroxide; n-butyllithium; tris-(o-tolyl)phosphine; palladium diacetate; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1.1: Suzuki-Miyaura coupling;
DOI:10.1002/adsc.200505173