N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-4-(1,1-dimethylethoxy)-4-oxo-2(R)-(4-thiazolylmethyl)butanamide

Base Information

Chemical Name:N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-4-(1,1-dimethylethoxy)-4-oxo-2(R)-(4-thiazolylmethyl)butanamide
CAS No.:160447-28-9
Molecular Formula:C₂₆H₄₄N₂O₅S
Molecular Weight:496.712
Hs Code.:

Synonyms:N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-4-(1,1-dimethylethoxy)-4-oxo-2(R)-(4-thiazolylmethyl)butanamide

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Chemical Property of N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-4-(1,1-dimethylethoxy)-4-oxo-2(R)-(4-thiazolylmethyl)butanamide

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Technology Process of N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-4-(1,1-dimethylethoxy)-4-oxo-2(R)-(4-thiazolylmethyl)butanamide

There total 5 articles about N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-4-(1,1-dimethylethoxy)-4-oxo-2(R)-(4-thiazolylmethyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: lithium hydroxide-hydrogen peroxide

: 2(S)-amino-1-cyclohexyl-3(R),4(S)-dihydroxy-6-methylheptane hydrochloride

: 160447-28-9
N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-4-(1,1-dimethylethoxy)-4-oxo-2(R)-(4-thiazolylmethyl)butanamide

Guidance literature:

Reference yield:

: 104882-45-3
(S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride

: 160447-27-8
2-thiazol-4-ylmethyl-succinic acid 4-tert-butyl ester

: 160447-28-9
N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-4-(1,1-dimethylethoxy)-4-oxo-2(R)-(4-thiazolylmethyl)butanamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; Yield given;
DOI:10.1016/S0968-0896(98)00265-X

Reference yield:

: 160447-17-6
3-(5-bromo-1,4-dioxopentyl)-4(S)-(1-methylethyl)-2-oxazolidinone

: 160447-28-9
N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-4-(1,1-dimethylethoxy)-4-oxo-2(R)-(4-thiazolylmethyl)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / tetrahydrofuran / 25 °C

2: 86 percent / NaHMDS / tetrahydrofuran / -78 °C / 1.) 45 min, 2.) 2 h

3: 30 percent H₂O₂, LiOH*H₂O / tetrahydrofuran; H₂O / 25 °C

4: i-Pr₂NEt, BOP*PF₆ / dimethylformamide / 25 °C

With lithium hydroxide; dihydrogen peroxide; sodium hexamethyldisilazane; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00265-X