104882-45-3

Basic information

• Product Name: (S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride
• Synonyms: (S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride
• CAS NO: 104882-45-3
• Molecular Weight: 279.851
• Mol File: 104882-45-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride(104882-45-3)
• EPA Substance Registry System: (S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride(104882-45-3)

Safety Data

• Hazardous Substances Data: 104882-45-3(Hazardous Substances Data)

Upstream product

• 131550-34-0 (S)-2-Cyclohexyl-1-((4R,5S)-5-isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethylamine 
• 117161-13-4 (4S,5R)-4-cyclohexylmethyl-5-<(1'S)-1'-hydroxy-3-methylbutyl>oxazolidin-2-one 
• 141364-54-7 (4S,5R)-2,2-Dimethyl-4-(2-methylpropan-1-yl)-5-(hydroxymethyl)-1,3-dioxolane 
• 139727-13-2 (4S,5R)-2,2-Dimethyl-4-(2-methyl-1-propenyl)-5-(hydroxymethyl)-1,3-dioxolane 
• 141364-53-6 N'-[(S)-2-Cyclohexyl-1-((4R,5S)-5-isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-N,N-dimethyl-hydrazine 
• 147879-36-5 (3R,4S)-3,4-Dihydroxy-6-methylhept-1-ene 
• 139727-17-6 (4S,5R)-2,2-Dimethyl-4-(2-methylpropan-1-yl)-5-vinyl-1,3-dioxolane 
• 147879-37-6 (2S,3S)-2,3-dihydroxy-5-methyl-4-hexenoic acid acetonide 
• 147879-38-7 methyl (2S,3S)-2,3-dihydroxy-5-methyl-4-hexenoate acetonide 
• 139727-18-7 (4S,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde 
• 141364-52-5 (4S,5S)-2,2-Dimethyl-4-(2-methylpropyl)-5-formyl-1,3-dioxolane dimethyl hydrazone 
• 35166-78-0 cyclohexylmethyl magnesium bromide 
• 130914-06-6 (4R,5R)-4-<(S)-(1-N-Benzylamino-2-cyclohexyl)ethyl>-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane 
• 139056-97-6 (2R,3R,4S)-4-(N-Benzyl-N-methoxycarbonyl)amino-1-benzyloxy-5-cyclohexylpentane-2,3-diol 

Downstream Products

• 104882-10-2 (2S,3R,4S)-2-[(tert-butyloxycarbonyl)amino]-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 124156-59-8 (2'S,3'R,4'S)-2-<1-methyl>-1,2,3,4-tetrahydropyrrolo<3,4-b>indol-3-one 
• 124156-58-7 (1'S,2''S,3''R,4''S)-2-<1--3-methylbutyl>-1,2,3,4-tetrahydropyrrolo<3,4-b>indol-3-one 
• 124262-95-9 (1'R,2''S,3''R,4''S)-2-<1-pentyl>-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol-1-one 
• 124175-18-4 (1'S,2''S,3''R,4''S)-2-<1-pentyl>-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol-1-one 
• 124223-57-0 (1'R,2''S,3''R,4''S)-2-<1--2-(4-thiazolyl)ethyl>-1,2,3,4-tetrahydropyrrolo<3,4-b>indol-3-one 
• 124156-56-5 (1'S,2''S,3''R,4''S)-2-<1--2-(4-thiazolyl)ethyl>-1,2,3,4-tetrahydropyrrolo<3,4-b>indol-3-one 
• 124223-58-1 (1'R,2''S,3''R,4''S)-2-<1--2-(3-pyrazolyl)ethyl>-1,2,3,4-tetrahydropyrrolo<3,4-b>indol-3-one 
• 124156-57-6 (1'S,2''S,3''R,4''S)-2-<1--2-(3-pyrazolyl)ethyl>-1,2,3,4-tetrahydropyrrolo<3,4-b>indol-3-one 
• 124223-56-9 (1'R,2''S,3''R,4''S)-2-<1--2-(4-imidazolyl)ethyl>-1,2,3,4-tetrahydropyrrolo<3,4-b>indol-3-one 
• 124156-55-4 (1'S,2''S,3''R,4''S)-2-<1--2-(4-imidazolyl)ethyl>-1,2,3,4-tetrahydropyrrolo<3,4-b>indol-3-one 
• 136010-42-9 N-(tert-butoxycarbonyl)-4-thiazolylalaninyl amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 116148-99-3 {(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-ethyl}-methyl-carbamic acid tert-butyl ester 
• 127953-03-1 PD 132002 

Relevant articles and documents

Dipeptide Isosteres. 1. Synthesis of Dihydroxyethylene Dipeptide Isosteres via Diastereoselective Additions of Alkyllithium Reagents to N,N-Dimethylhydrazones. Preparation of Renin and HIV-1 Protease Inhibitor Transition-State Mimics

The amino and diamino dihydroxyethylene dipeptide isosteres 19a,b and 23 are important intermediates for the preparation of inhibitors of human renin and HIV-1 protease, respectively.A general synthetic strategy was developed to access both dipeptide isos

Novel synthesis of three types of C-terminal components of renin inhibitors from unnatural (2S,3S)-tartaric acid

The addition reaction of cyclohexylmethylmagnesium bromide with the imine prepared from unnatural (2S,3S)-tartaric acid was found to proceed in a highly stereoselective manner in the presence of cerium(III) chloride. A chelation-controlled mechanism could