104882-45-3

Upstream product

• 117161-13-4 (4S,5R)-4-cyclohexylmethyl-5-<(1'S)-1'-hydroxy-3-methylbutyl>oxazolidin-2-one 
• 35166-78-0 cyclohexylmethyl magnesium bromide 
• 131451-93-9 (4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(R)-(2-benzyloxy-1-methanesulfonyloxy)ethyl>oxazolidin-2-one 
• 131451-94-0 (4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(R)-(2-hydroxy-1-methanesulfonyloxy)ethyl>oxazolidin-2-one 
• 131451-97-3 (4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-3-methyl)butyl>oxazolidin-2-one 
• 131451-95-1 (4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-oxiran-2-yl>oxazolidin-2-one 
• 139056-96-5 (4R,5R)-4-<(S)-(1-(N-Benzyl-N-methoxycarbonyl)amino-2-cyclohexyl)ethyl>-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane 
• 139056-97-6 (2R,3R,4S)-4-(N-Benzyl-N-methoxycarbonyl)amino-1-benzyloxy-5-cyclohexylpentane-2,3-diol 
• 130914-06-6 (4R,5R)-4-<(S)-(1-N-Benzylamino-2-cyclohexyl)ethyl>-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane 
• 141364-52-5 (4S,5S)-2,2-Dimethyl-4-(2-methylpropyl)-5-formyl-1,3-dioxolane dimethyl hydrazone 
• 139727-18-7 (4S,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde 
• 147879-38-7 methyl (2S,3S)-2,3-dihydroxy-5-methyl-4-hexenoate acetonide 
• 147879-37-6 (2S,3S)-2,3-dihydroxy-5-methyl-4-hexenoic acid acetonide 
• 139727-17-6 (4S,5R)-2,2-Dimethyl-4-(2-methylpropan-1-yl)-5-vinyl-1,3-dioxolane 

Downstream Products

• 225377-74-2 N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-2(R)-<2-(1,1-dimethylethoxy)-2-oxoethyl>pentanamide 
• 160447-08-5 N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-2(R)-(cyclopropylmethyl)-4-(1,1-dimethylethoxy)-4-oxobutanamide 
• 225378-03-0 N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-4-(1,1-dimethylethoxy)-4-oxo-2(S)-(2-thiazolylmethyl)butanamide 
• 225377-83-3 N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-4-(1,1-dimethylethoxy)-4-oxo-2(S)-(2-thienylmethyl)butanamide 
• 160447-28-9 N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-4-(1,1-dimethylethoxy)-4-oxo-2(R)-(4-thiazolylmethyl)butanamide 
• 160447-13-2 N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-4-oxo-4-(phenylmethoxy)-2(R)-<<(1-triphenylmethyl)-1H-imidazol-4-yl>methyl>butanamide 
• 130317-48-5 (S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid ((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-amide 
• 130316-88-0 (2S,4S)-3-aza-2-butyl-4-<<4-(1,3-dioxabutyl)piperidin-1-yl>carbonyl>-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 130316-76-6 (2S,4S)-3-aza-4-(morpholinocarbonyl)-2-butyl-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 141117-09-1 (2R,4S)-3-aza-4-(morpholinocarbonyl)-2-butyl-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 130316-65-3 (2S,4S)-3-aza-4-(tert-butoxycarbonyl)-2-isobutyl-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 130316-65-3 (2R,4S)-3-aza-4-(tert-butoxycarbonyl)-2-isobutyl-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 130316-75-5 (4S)-3-aza-4-(morpholinocarbonyl)-2-methyl-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 130316-75-5 (4R)-3-aza-4-(morpholinocarbonyl)-2-methyl-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 

Relevant academic research and scientific papers

Dipeptide Isosteres. 1. Synthesis of Dihydroxyethylene Dipeptide Isosteres via Diastereoselective Additions of Alkyllithium Reagents to N,N-Dimethylhydrazones. Preparation of Renin and HIV-1 Protease Inhibitor Transition-State Mimics

The amino and diamino dihydroxyethylene dipeptide isosteres 19a,b and 23 are important intermediates for the preparation of inhibitors of human renin and HIV-1 protease, respectively.A general synthetic strategy was developed to access both dipeptide isos

A practical synthesis of the dihydroxyethylene dipeptide isostere, (2S, 3R, 4S) 2-[(tert-butyloxycarbonyl)amino]-1-cyclohexyl-3,4-dihydroxy-6-methylheptane, from D-isoascorbic acid

The N-Boc dihydroxyethylene dipeptide isostere 7 and its N-Boc 3-(thiazol-4-yl)alanyl derivative 8 were synthesized, without purification of intermediates, from (4S,5R)-2,2-dimethyl-4-(2-methylpropyl)-5-hydroxymethyl-1,3-dioxolane (3b), in 24 and 32% over

Novel synthesis of three types of C-terminal components of renin inhibitors from unnatural (2S,3S)-tartaric acid

The addition reaction of cyclohexylmethylmagnesium bromide with the imine prepared from unnatural (2S,3S)-tartaric acid was found to proceed in a highly stereoselective manner in the presence of cerium(III) chloride. A chelation-controlled mechanism could

Novel Synthesis of (2S,3R,4S)-4-Amino-5-cyclohexyl-1-morpholino-2,3-pentanediol and (2S,3R,4S)-2-Amino-1-cyclohexyl-6-methyl-3,4-heptandiol, the C-Terminal Components of Renin Inhibitors

The title synthesis could be accomplished in a highly stereo-and regioselective manner by employing epoxide formation with inversion of configuration followed by epoxide opening with a nucleophile.