8-cyclohexyl-5-[[(methylsulfonyl)amino]carbonyl]-1,12b-dihydro-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid

Base Information

Chemical Name:8-cyclohexyl-5-[[(methylsulfonyl)amino]carbonyl]-1,12b-dihydro-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid
CAS No.:1033905-34-8
Molecular Formula:C₂₈H₃₀N₂O₆S
Molecular Weight:522.622
Hs Code.:

Synonyms:8-cyclohexyl-5-[[(methylsulfonyl)amino]carbonyl]-1,12b-dihydro-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid

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Chemical Property of 8-cyclohexyl-5-[[(methylsulfonyl)amino]carbonyl]-1,12b-dihydro-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid

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Technology Process of 8-cyclohexyl-5-[[(methylsulfonyl)amino]carbonyl]-1,12b-dihydro-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid

There total 13 articles about 8-cyclohexyl-5-[[(methylsulfonyl)amino]carbonyl]-1,12b-dihydro-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: C₃₁H₃₄N₂O₆S

: 1033905-34-8
8-cyclohexyl-5-[[(methylsulfonyl)amino]carbonyl]-1,12b-dihydro-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid

Guidance literature:: C₃₁H₃₄N₂O₆S; With methanol; sodium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 3h;

With hydrogenchloride; water; In tetrahydrofuran; methanol;

Reference yield: 96.0%

: 1033905-37-1
C₂₉H₃₂N₂O₆S

: 1033905-34-8
8-cyclohexyl-5-[[(methylsulfonyl)amino]carbonyl]-1,12b-dihydro-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid

Guidance literature:: C₂₉H₃₂N₂O₆S; With methanol; sodium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; ethyl acetate;

Reference yield:

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 1033905-34-8
8-cyclohexyl-5-[[(methylsulfonyl)amino]carbonyl]-1,12b-dihydro-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 - 3 h / 90 °C / Heating / reflux

1.2: 1 h / 0 - 20 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 - 2 h / 22 - 50 °C

2.2: 21 - 24 h / 20 - 30 °C

3.1: lithium chloride / ethanol; toluene / 0.25 h

3.2: 0.17 h

3.3: 20 h / 70 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 55 - 60 °C

5.1: sodium hydride / dimethyl sulfoxide / 0.5 - 0.75 h / 20 °C

5.2: 3 - 4 h / 50 °C

6.1: trifluoroacetic acid / dichloromethane / 8 - 12 h / 20 °C

7.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 50 °C

7.2: 20 h

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 20 °C

With lithium hydroxide; sodium hydroxide; water; sodium hydride; caesium carbonate; 1,1'-carbonyldiimidazole; trifluoroacetic acid; lithium chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;