(2,4-diisopropoxy-6-vinyl-phenyl)phosphonic acid diethyl ester

Base Information

• Chemical Name: (2,4-diisopropoxy-6-vinyl-phenyl)phosphonic acid diethyl ester
• CAS No.: 859103-28-9
• Molecular Formula: C₁₈H₂₉O₅P
• Molecular Weight: 356.399
• Mol file: 859103-28-9.mol

Synonyms:(2,4-diisopropoxy-6-vinyl-phenyl)phosphonic acid diethyl ester

Chemical Property of (2,4-diisopropoxy-6-vinyl-phenyl)phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2,4-diisopropoxy-6-vinyl-phenyl)phosphonic acid diethyl ester

There total 5 articles about (2,4-diisopropoxy-6-vinyl-phenyl)phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

trifluoromethanesulfonic acid [2-(diethoxyphosphoryl)-3,5-diisopropoxy-phenyl]ester (859103-24-5) + tri-n-butyl(vinyl)tin (7486-35-3) → (2,4-diisopropoxy-6-vinyl-phenyl)phosphonic acid diethyl ester (859103-28-9)

Guidance literature:

With lithium chloride; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

DOI:10.1016/j.tetlet.2005.04.104

Reference yield:

phosphoric acid (3,5-di-isopropoxy-phenyl)ester diethyl ester (859103-16-5) → (2,4-diisopropoxy-6-vinyl-phenyl)phosphonic acid diethyl ester (859103-28-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / LDA / tetrahydrofuran / -78 °C

2: NaH; 12-crown-4 / tetrahydrofuran

3: LiCl / Pd(PPh₃)2Cl₂ / dimethylformamide

With (1,4,7,10-tetraoxacyclododecane); sodium hydride; lithium chloride; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; 1: phospho-Fries rearrangement;

DOI:10.1016/j.tet.2007.07.042

Reference yield:

(2-hydroxy-4,6-diisopropoxy-phenyl)phosphonic acid diethyl ester (859103-20-1) → (2,4-diisopropoxy-6-vinyl-phenyl)phosphonic acid diethyl ester (859103-28-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH; 12-crown-4 / tetrahydrofuran

2: LiCl / Pd(PPh₃)2Cl₂ / dimethylformamide

With (1,4,7,10-tetraoxacyclododecane); sodium hydride; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2007.07.042

upstream raw materials:

trifluoromethanesulfonic acid [2-(diethoxyphosphoryl)-3,5-diisopropoxy-phenyl]ester

tri-n-butyl(vinyl)tin

phosphoric acid (3,5-di-isopropoxy-phenyl)ester diethyl ester

(2-hydroxy-4,6-diisopropoxy-phenyl)phosphonic acid diethyl ester

Downstream raw materials:

(2,4-diisopropoxy-6-vinyl-phenyl)phosphonic acid monoethyl ester

ethyl 2-[6-(1,3-dithiane)undec-10-enyl] (4,6-diisopropoxy-2-vinylphenyl)phosphonate