(2-hydroxy-4,6-diisopropoxy-phenyl)phosphonic acid diethyl ester

Base Information

• Chemical Name: (2-hydroxy-4,6-diisopropoxy-phenyl)phosphonic acid diethyl ester
• CAS No.: 859103-20-1
• Molecular Formula: C₁₆H₂₇O₆P
• Molecular Weight: 346.361
• Mol file: 859103-20-1.mol

Synonyms:(2-hydroxy-4,6-diisopropoxy-phenyl)phosphonic acid diethyl ester

Chemical Property of (2-hydroxy-4,6-diisopropoxy-phenyl)phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-hydroxy-4,6-diisopropoxy-phenyl)phosphonic acid diethyl ester

There total 4 articles about (2-hydroxy-4,6-diisopropoxy-phenyl)phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

phosphoric acid (3,5-di-isopropoxy-phenyl)ester diethyl ester (859103-16-5) + phosphonic acid diethyl ester (762-04-9) → (2-hydroxy-4,6-diisopropoxy-phenyl)phosphonic acid diethyl ester (859103-20-1)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

DOI:10.1016/j.tetlet.2005.04.104

Reference yield: 92.0%

phosphoric acid (3,5-di-isopropoxy-phenyl)ester diethyl ester (859103-16-5) → (2-hydroxy-4,6-diisopropoxy-phenyl)phosphonic acid diethyl ester (859103-20-1)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/j.tet.2007.07.042

Reference yield:

3,5-dihydroxyphenol (108-73-6) → (2-hydroxy-4,6-diisopropoxy-phenyl)phosphonic acid diethyl ester (859103-20-1)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃; KI / dimethylformamide / 72 h / 50 °C

2: CCl₄ / acetonitrile

3: 92 percent / LDA / tetrahydrofuran / -78 °C

With tetrachloromethane; potassium carbonate; potassium iodide; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 3: phospho-Fries rearrangement;

DOI:10.1016/j.tet.2007.07.042

upstream raw materials:

phosphoric acid (3,5-di-isopropoxy-phenyl)ester diethyl ester

phosphonic acid diethyl ester

3,5-dihydroxyphenol

3,5-di-(isopropoxy)phenol

Downstream raw materials:

trifluoromethanesulfonic acid [2-(diethoxyphosphoryl)-3,5-diisopropoxy-phenyl]ester

ethyl 2-[6-(1,3-dithiane)undec-10-enyl] (4,6-diisopropoxy-2-vinylphenyl)phosphonate

(2,4-diisopropoxy-6-vinyl-phenyl)phosphonic acid monoethyl ester

(2,4-diisopropoxy-6-vinyl-phenyl)phosphonic acid diethyl ester