ethyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)but-3-enoate

Base Information

Chemical Name:ethyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)but-3-enoate
CAS No.:1051442-83-1
Molecular Formula:C₁₇H₂₄F₃NO₃Si
Molecular Weight:375.463
Hs Code.:

Synonyms:ethyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)but-3-enoate

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Chemical Property of ethyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)but-3-enoate

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Technology Process of ethyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)but-3-enoate

There total 3 articles about ethyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)but-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 143505-42-4
1-[(4-methylphenyl)sulfinyl]-2-(trimethylsilyl)ethane

: (E)-ethyl 3,3,3-trifluoro-2-[(4-methoxyphenyl)imino]propanoate

: 1051442-83-1
ethyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)but-3-enoate

Guidance literature:: 1-[(4-methylphenyl)sulfinyl]-2-(trimethylsilyl)ethane; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -10 ℃; for 0.333333h;

(E)-ethyl 3,3,3-trifluoro-2-[(4-methoxyphenyl)imino]propanoate; In tetrahydrofuran; hexane; at -50 - -30 ℃; for 3h; Further stages.;
DOI:10.1016/j.jfluchem.2007.05.006

Reference yield:

: 75999-66-5
(Z)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidoyl chloride

: 1051442-83-1
ethyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)but-3-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium iodide / acetone

2.1: K₂CO₃ / Pd₂(dba)3 / toluene; dimethylformamide

3.1: lithium bis(trimethylsilyl)amide / hexane; tetrahydrofuran / 0.33 h / -10 °C

3.2: 30 percent / tetrahydrofuran; hexane / 3 h / -50 - -30 °C

With potassium carbonate; sodium iodide; lithium hexamethyldisilazane; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/j.jfluchem.2007.05.006

Reference yield:

: 134481-27-9
N-(p-Anisyl)-2,2,2-trifluoroacetimidoyl iodide

: 1051442-83-1
ethyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)but-3-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: K₂CO₃ / Pd₂(dba)3 / toluene; dimethylformamide

2.1: lithium bis(trimethylsilyl)amide / hexane; tetrahydrofuran / 0.33 h / -10 °C

2.2: 30 percent / tetrahydrofuran; hexane / 3 h / -50 - -30 °C

With potassium carbonate; lithium hexamethyldisilazane; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.jfluchem.2007.05.006