(1r,1'S,4S)-4-methoxy-5''-methyl-6'-(5-prop-1-yn-1-ylpyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

Base Information

Chemical Name:(1r,1'S,4S)-4-methoxy-5''-methyl-6'-(5-prop-1-yn-1-ylpyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine
CAS No.:1384082-96-5
Molecular Formula:C₂₆H₂₈N₄O
Molecular Weight:412.535
Hs Code.:

Synonyms:(1r,1'S,4S)-4-methoxy-5''-methyl-6'-(5-prop-1-yn-1-ylpyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

Suppliers and Price of (1r,1'S,4S)-4-methoxy-5''-methyl-6'-(5-prop-1-yn-1-ylpyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of (1r,1'S,4S)-4-methoxy-5''-methyl-6'-(5-prop-1-yn-1-ylpyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of (1r,1'S,4S)-4-methoxy-5''-methyl-6'-(5-prop-1-yn-1-ylpyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

There total 10 articles about (1r,1'S,4S)-4-methoxy-5''-methyl-6'-(5-prop-1-yn-1-ylpyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383982-62-4
(1r,4r)-4-methoxy-5''-methyl-6'-(5-prop-1-yn-1-ylpyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

: 1384082-96-5
(1r,1'S,4S)-4-methoxy-5''-methyl-6'-(5-prop-1-yn-1-ylpyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

: 1383982-64-6
(1r,1’R,4R)-4-methoxy-5”-methyl-6’-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3’H-dispiro[cyclohexane-1,2’-indene-1’2”-imidazol]-4”-amine

Guidance literature:: With diethylamine; In methanol; carbon dioxide;

Reference yield:

: 1245515-16-5
6'-bromo-4-methoxyspiro[cyclohexane-1,2'-indene]-1'(3'H)-one

: 1384082-96-5
(1r,1'S,4S)-4-methoxy-5''-methyl-6'-(5-prop-1-yn-1-ylpyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

: 1383982-64-6
(1r,1’R,4R)-4-methoxy-5”-methyl-6’-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3’H-dispiro[cyclohexane-1,2’-indene-1’2”-imidazol]-4”-amine

Guidance literature:: Multi-step reaction with 6 steps

1: titanium(IV) tetraethanolate / 2-methyltetrahydrofuran / 26 h / Reflux

2: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C / Inert atmosphere

3: methanol / 15 h / 60 °C / Inert atmosphere

4: ammonia / methanol / 74 °C

5: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 2-methyltetrahydrofuran / 1 h / 100 °C / Microwave irradiation

6: diethylamine / carbon dioxide; methanol

With hydrogenchloride; titanium(IV) tetraethanolate; ammonia; potassium carbonate; diethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 2-methyltetrahydrofuran; 1,4-dioxane; methanol; carbon dioxide; water;

Reference yield:

: 1383985-58-7
6'-bromo-4-methoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-imine

: 1384082-96-5
(1r,1'S,4S)-4-methoxy-5''-methyl-6'-(5-prop-1-yn-1-ylpyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

: 1383982-64-6
(1r,1’R,4R)-4-methoxy-5”-methyl-6’-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3’H-dispiro[cyclohexane-1,2’-indene-1’2”-imidazol]-4”-amine

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 15 h / 60 °C / Inert atmosphere

2: ammonia / methanol / 74 °C

3: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 2-methyltetrahydrofuran / 1 h / 100 °C / Microwave irradiation

4: diethylamine / carbon dioxide; methanol

With ammonia; potassium carbonate; diethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 2-methyltetrahydrofuran; methanol; carbon dioxide; water;