(R,E)-methyl 2-(3-(acetylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate

Base Information

Chemical Name:(R,E)-methyl 2-(3-(acetylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate
CAS No.:855473-48-2
Molecular Formula:C₃₀H₂₆ClNO₃S
Molecular Weight:516.06
Hs Code.:

Synonyms:(R,E)-methyl 2-(3-(acetylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate

Suppliers and Price of (R,E)-methyl 2-(3-(acetylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-[(3R)-3-(Acetylthio)-3-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]propyl]-BenzoicAcidMethylEster
250mg
$ 1320.00

Total 0 raw suppliers

Chemical Property of (R,E)-methyl 2-(3-(acetylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate

Chemical Property:

Purity/Quality:: 2-[(3R)-3-(Acetylthio)-3-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]propyl]-BenzoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 2-[(3R)-3-(Acetylthio)-3-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]propyl]-Benzoic Acid Methyl Ester is a reagent in the preparation of Montelukast Sodium Salt (M568000) which is a selective leukotriene D4-receptor antagonist. Used as an antiasthmatic.

Technology Process of (R,E)-methyl 2-(3-(acetylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate

There total 3 articles about (R,E)-methyl 2-(3-(acetylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 906107-36-6
Methyl [S-(E)]-2-[3-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-methanesulfonyloxy-propyl] benzoate

: 507-09-5
tiolacetic acid

: 855473-48-2
(R,E)-methyl 2-(3-(acetylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate

Guidance literature:: With triethylamine; In toluene; at 20 - 45 ℃; for 3.58333h;

Reference yield: 57.0%

: 906107-36-6
Methyl [S-(E)]-2-[3-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-methanesulfonyloxy-propyl] benzoate

: 10387-40-3
potassium thioacetate

: 855473-48-2
(R,E)-methyl 2-(3-(acetylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate

Guidance literature:: In DMF (N,N-dimethyl-formamide); toluene; at 20 ℃; Product distribution / selectivity;

Reference yield:

: 181139-72-0
methyl-[(E)]-2-[3(S)-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxypropyl] benzoate

: 10387-40-3
potassium thioacetate

: 855473-48-2
(R,E)-methyl 2-(3-(acetylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate

Guidance literature:: methanesulfonyl chloride; methyl-[(E)]-2-[3(S)-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxypropyl] benzoate; With triethylamine; In water; toluene; at -30 - 0 ℃; for 1.88333h;

potassium thioacetate; In DMF (N,N-dimethyl-formamide); toluene; at 40 - 42 ℃; for 3.5h; Product distribution / selectivity;