4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbonitrile

Base Information

Chemical Name:4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbonitrile
CAS No.:554416-43-2
Molecular Formula:C₃₆H₅₅NO₄Si₂
Molecular Weight:622.008
Hs Code.:

4-[4-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-5-(<i>tert</i>-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbonitrile

Synonyms:4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbonitrile

Suppliers and Price of 4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbonitrile

There total 12 articles about 4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 554416-23-8
5-(4-methoxy-benzyloxy)-pent-2-ynoic acid ethyl ester

: 554416-43-2
4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbonitrile

Guidance literature:: Multi-step reaction with 12 steps

1.1: copper(I) iodide / tetrahydrofuran; diethyl ether / 0 °C

1.2: tetrahydrofuran; diethyl ether / 1 h / -78 - -45 °C

1.3: 95 percent / iodine / tetrahydrofuran; diethyl ether / 3 h / -78 - 0 °C

2.1: DIBAL-H / CH₂Cl₂; hexane / 2 h / -78 °C

3.1: 100 percent / imidazole / CH₂Cl₂ / 15 h / 20 °C

4.1: 75 percent / Et₃N / bis(triphenylphosphine)palladium(II) dichloride / 1-methyl-pyrrolidin-2-one / 44 h / 70 °C / 15514.4 Torr

5.1: 66 percent / DIBAL-H / toluene / 1.5 h / -78 °C

6.1: 100 percent / imidazole / CH₂Cl₂ / 0 - 20 °C

7.1: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂; H₂O / 1.08 h / 20 °C

8.1: triethylamine / CH₂Cl₂ / 1.5 h / 0 °C

9.1: 5.09 g / sodium iodide / acetone / 2.5 h / Heating

10.1: t-butyllithium / tetrahydrofuran; pentane / 2 h / -78 °C

10.2: 62 percent / tetrahydrofuran; pentane / 16 h / -100 - -78 °C

11.1: 90 percent / aqueous oxalic acid / diethyl ether / 2.5 h / 20 °C

12.1: diethyl cyanophosphonate / tetrahydrofuran / 1 h / 20 °C

12.2: samarium; diiodoethane; methanol / tetrahydrofuran / 2 h / 23 °C

With 1H-imidazole; copper(l) iodide; diethyl cyanophosphonate; tert.-butyl lithium; oxalic acid; diisobutylaluminium hydride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium iodide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; hexane; dichloromethane; water; acetone; toluene; pentane;
DOI:10.1016/S0040-4020(03)00372-7

Reference yield:

: 554416-46-5
(E)-2-Iodo-5-(4-methoxy-benzyloxy)-3-methyl-pent-2-en-1-ol

: 554416-43-2
4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbonitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: 100 percent / imidazole / CH₂Cl₂ / 15 h / 20 °C

2.1: 75 percent / Et₃N / bis(triphenylphosphine)palladium(II) dichloride / 1-methyl-pyrrolidin-2-one / 44 h / 70 °C / 15514.4 Torr

3.1: 66 percent / DIBAL-H / toluene / 1.5 h / -78 °C

4.1: 100 percent / imidazole / CH₂Cl₂ / 0 - 20 °C

5.1: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂; H₂O / 1.08 h / 20 °C

6.1: triethylamine / CH₂Cl₂ / 1.5 h / 0 °C

7.1: 5.09 g / sodium iodide / acetone / 2.5 h / Heating

8.1: t-butyllithium / tetrahydrofuran; pentane / 2 h / -78 °C

8.2: 62 percent / tetrahydrofuran; pentane / 16 h / -100 - -78 °C

9.1: 90 percent / aqueous oxalic acid / diethyl ether / 2.5 h / 20 °C

10.1: diethyl cyanophosphonate / tetrahydrofuran / 1 h / 20 °C

10.2: samarium; diiodoethane; methanol / tetrahydrofuran / 2 h / 23 °C

With 1H-imidazole; diethyl cyanophosphonate; tert.-butyl lithium; oxalic acid; diisobutylaluminium hydride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium iodide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; dichloromethane; water; acetone; toluene; pentane;
DOI:10.1016/S0040-4020(03)00372-7

Reference yield:

: 2408-36-8
lithium cyanide

: 554416-31-8
4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxan-5-one

: 554416-43-2
4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbonitrile

: 554416-32-9
4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbonitrile

Guidance literature:: lithium cyanide; 4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxan-5-one; With diethyl cyanophosphonate; In tetrahydrofuran; at 20 ℃; for 1h;

With methanol; samarium; 1,1-diiodoethane; In tetrahydrofuran; at 23 ℃; for 2h;
DOI:10.1016/S0040-4020(03)00372-7