Boc-D-Pro-Aib-L-Phe-NMe₂

Base Information

Chemical Name:Boc-D-Pro-Aib-L-Phe-NMe₂
CAS No.:1148044-87-4
Molecular Formula:C₂₅H₃₈N₄O₅
Molecular Weight:474.601
Hs Code.:

Synonyms:Boc-D-Pro-Aib-L-Phe-NMe₂

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Boc-D-Pro-Aib-L-Phe-NMe₂

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Technology Process of Boc-D-Pro-Aib-L-Phe-NMe₂

There total 8 articles about Boc-D-Pro-Aib-L-Phe-NMe₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Boc-D-Pro-Aib-L-Phe-OH

: 506-59-2
N,N-dimethylammonium chloride

: 1148044-87-4
Boc-D-Pro-Aib-L-Phe-NMe₂

Guidance literature:: Boc-D-Pro-Aib-L-Phe-OH; N,N-dimethylammonium chloride; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; at 23 ℃; for 14h; Inert atmosphere;

With hydrogenchloride; In water;

Reference yield:

: C₁₅H₂₃N₃O₂*ClH

: 37784-17-1,59433-50-0
N-(tert-butoxycarbonyl)-D-proline

: 1148044-87-4
Boc-D-Pro-Aib-L-Phe-NMe₂

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 21 - 23 ℃; for 3h;
DOI:10.1021/jacs.5b07726

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1148044-87-4
Boc-D-Pro-Aib-L-Phe-NMe₂

Guidance literature:: Multi-step reaction with 5 steps

1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 21 - 23 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 21 - 23 °C

3: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 42 h / 21 - 23 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 21 - 23 °C

5: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 42 h / 21 - 23 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jo402828f